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dc.contributor.authorAnand, A
dc.contributor.authorBanik, A
dc.contributor.authorThakur, K
dc.contributor.authorMasters, CL
dc.date.available2014-05-22T08:37:47Z
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.available2012-04-24
dc.date.issued2012-11-01
dc.identifierpii: CAR-EPUB-20120612-1
dc.identifier.citationAnand, A., Banik, A., Thakur, K. & Masters, C. L. (2012). The Animal Models of Dementia and Alzheimer's Disease for Pre-Clinical Testing and Clinical Translation. CURRENT ALZHEIMER RESEARCH, 9 (9), pp.1010-1029. https://doi.org/10.2174/156720512803569055.
dc.identifier.issn1567-2050
dc.identifier.urihttp://hdl.handle.net/11343/33298
dc.descriptionC5 - Other Refereed Contribution to Refereed Journals
dc.description.abstractDementia is a clinical syndrome with abnormal degree of memory loss and impaired ability to recall events from the past often characterized by Alzheimer's disease. The various strategies to treat dementia need validation of novel compounds in suitable animal models for testing their safety and efficacy. These may include novel anti-amnesic drugs derived from synthetic chemistry or those derived from traditional herbal sources. Multiple approaches have been adopted to create reliable animal models ranging from rodents to non-human primates, where the animals are exposed to a predetermined injury or causing genetic ablation across specific regions of brain suspected to affect learning functions. In this review various animal models for Alzheimer's disease and treatment strategies in development of anti dementia drugs are discussed and an attempt has been made to provide a comprehensive report of the latest developments in the field.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.subjectClinical Pharmacology and Therapeutics; Neurology and Neuromuscular Diseases; Mental Health
dc.titleThe Animal Models of Dementia and Alzheimer's Disease for Pre-Clinical Testing and Clinical Translation
dc.typeJournal Article
dc.identifier.doi10.2174/156720512803569055
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentCentre For Neuroscience Research
melbourne.source.titleCURRENT ALZHEIMER RESEARCH
melbourne.source.volume9
melbourne.source.issue9
melbourne.source.pages1010-1029
dc.research.codefor111502
dc.research.codefor110904
dc.research.codeseo2008920410
melbourne.publicationid197177
melbourne.elementsid400738
melbourne.contributor.authorMasters, Colin
dc.identifier.eissn1875-5828
pubs.acceptance.date2012-04-24
melbourne.accessrightsThis item is currently not available from this repository


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