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    Retinal Venular Calibre is Increased in Patients with Autoimmune Rheumatic Disease: A Case-Control Study

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    Author
    Okada, M; Wong, TY; Kawasaki, R; Baharuddin, NB; Colville, D; Buchanan, R; Savige, J
    Date
    2013-06-01
    Source Title
    CURRENT EYE RESEARCH
    Publisher
    INFORMA HEALTHCARE
    University of Melbourne Author/s
    Kawasaki, Ryo; Wong, Tien; Savige, Judith; COLVILLE, DEBORAH JAN; Buchanan, Russell; OKADA, MALI; BAHARUDDIN, NORASYIQIN
    Affiliation
    Medicine - Royal Melbourne Hospital
    Metadata
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    Document Type
    Journal Article
    Citations
    Okada, M., Wong, T. Y., Kawasaki, R., Baharuddin, N. B., Colville, D., Buchanan, R. & Savige, J. (2013). Retinal Venular Calibre is Increased in Patients with Autoimmune Rheumatic Disease: A Case-Control Study. CURRENT EYE RESEARCH, 38 (6), pp.685-690. https://doi.org/10.3109/02713683.2012.754046.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33315
    DOI
    10.3109/02713683.2012.754046
    Description

    C1 - Journal Articles Refereed

    Abstract
    AIM: To examine retinal vessel calibre in autoimmune rheumatic disease. MATERIALS AND METHODS: Patients with autoimmune rheumatic disease were recruited from a Rheumatology clinic. Retinal vessel calibre was measured from fundus photographs, and summarised as the central retinal artery and vein equivalents (CRAE and CRVE) using a semi-automated computer-assisted method. RESULTS: The 124 patients studied had rheumatoid arthritis (n = 76, 61%), systemic lupus erythematosus (n = 17, 14%), psoriatic arthritis (n = 11, 9%) or another rheumatological disease (n = 20, 16%). Retinal venular calibre was increased in patients with autoimmune rheumatic disease (+11.6 µm, 95% Confidence interval [CI] 3.8 - 19.3, p = 0.01) compared with other hospital patients, after adjusting for baseline differences. This increase was also present in the subgroup with rheumatoid arthritis (p = 0.01). Patients with a rheumatic disease and elevated C-reactive protein (CRP) levels had wider retinal venules than those with a lower CRP (mean CRVE: 247.8 ± 28.0 versus 216.6 ± 25.3, p < 0.01), and than other hospital patients with increased CRP (mean CRVE: 247.8 ± 28.0 versus 216.4 ± 25.9, p < 0.01). CONCLUSIONS: Individuals with an autoimmune rheumatic disease have wider retinal venules than other hospital patients. This increase in calibre may be due to the underlying inflammatory activity.
    Keywords
    Rheumatology and Arthritis; Ophthalmology; Cardiology (incl. Cardiovascular Diseases); Cardiovascular System and Diseases; Skeletal System and Disorders (incl. Arthritis)

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