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dc.contributor.authorGilmore, KJ
dc.contributor.authorKita, M
dc.contributor.authorHan, Y
dc.contributor.authorGelmi, A
dc.contributor.authorHiggins, MJ
dc.contributor.authorMoulton, SE
dc.contributor.authorClark, GM
dc.contributor.authorKapsa, R
dc.contributor.authorWallace, GG
dc.date.accessioned2014-05-22T08:47:08Z
dc.date.available2014-05-22T08:47:08Z
dc.date.issued2009-10-01
dc.identifierpii: S0142-9612(09)00684-X
dc.identifier.citationGilmore, K. J., Kita, M., Han, Y., Gelmi, A., Higgins, M. J., Moulton, S. E., Clark, G. M., Kapsa, R. & Wallace, G. G. (2009). Skeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components. BIOMATERIALS, 30 (29), pp.5292-5304. https://doi.org/10.1016/j.biomaterials.2009.06.059.
dc.identifier.issn0142-9612
dc.identifier.urihttp://hdl.handle.net/11343/33348
dc.description.abstractConducting polymers have been developed as substrates for in vitro studies with a range of cell types including electrically-excitable cells such as nerve and smooth muscle. The goal of this study was to optimise and characterise a range of polypyrrole materials to act as substrates for electrical stimulation of differentiating skeletal myoblasts. Although all of the polymer materials provided suitable substrates for myoblast adhesion and proliferation, significant differences became apparent under the low-serum conditions used for differentiation of primary myoblasts. The significance of the work lies in the design and control of polymer materials to facilitate different stages of skeletal muscle cell proliferation and/or differentiation, opening up opportunities for engineering of this tissue. This paper therefore constitutes not just a biocompatibility assessment but a comprehensive study of how synthesis conditions affect the final outcome in terms of cell response.
dc.languageEnglish
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofScientific publications, vol.14, 2004-2012
dc.subjectskeletal muscle
dc.subjectconducting polymer
dc.subjectcell differentiation
dc.subjectcell adhesion
dc.subjecttissue engineering
dc.subjectatomic force microscopy
dc.titleSkeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components
dc.typeJournal Article
dc.identifier.doi10.1016/j.biomaterials.2009.06.059
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.publication.statusPublished
melbourne.source.titleBiomaterials
melbourne.source.volume30
melbourne.source.issue29
melbourne.source.pages5292-5304
melbourne.publicationid205129
melbourne.elementsid587673
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorKapsa, Robert
dc.identifier.eissn1878-5905
melbourne.accessrightsThis item is currently not available from this repository


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