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    Conducting polymers, dual neurotrophins and pulsed electrical stimulation - Dramatic effects on neurite outgrowth

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    Author
    Thompson, BC; Richardson, RT; Moulton, SE; Evans, AJ; O'Leary, S; Clark, GM; Wallace, GG
    Date
    2010-01-25
    Source Title
    Journal of Controlled Release
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    Richardson, Rachael; O'Leary, Stephen; Clark, Graeme; NEIL, ALISON
    Metadata
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    Document Type
    Journal Article
    Citations
    Thompson, B. C., Richardson, R. T., Moulton, S. E., Evans, A. J., O'Leary, S., Clark, G. M. & Wallace, G. G. (2010). Conducting polymers, dual neurotrophins and pulsed electrical stimulation - Dramatic effects on neurite outgrowth. JOURNAL OF CONTROLLED RELEASE, 141 (2), pp.161-167. https://doi.org/10.1016/j.jconrel.2009.09.016.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33359
    DOI
    10.1016/j.jconrel.2009.09.016
    Abstract
    In this study the synergistic effect of delivering two neurotrophins simultaneously to encourage neuron survival and neurite elongation was explored. Neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) were incorporated into polypyrrole (PPy) during electrosynthesis and the amounts incorporated and released were determined using iodine-125 ((125)I) radio-labelled neurotrophins. Neurite outgrowth from cochlear neural explants grown on the conducting polymer was equivalent to that on tissue culture plastic but significantly improved with the incorporation of NT-3 and BDNF. Neurite outgrowth from explants grown on polymers containing both NT-3 and BDNF showed significant improvement over PPy doped only with NT-3, due to the synergistic effect of both neurotrophins. Neurite outgrowth was significantly improved when the polymer containing both neurotrophins was electrically stimulated. It is envisaged that when applied to the cochlear implant, these conducting and novel polymer films will provide a biocompatible substrate for storage and release of neurotrophins to help protect auditory neurons from degradation after sensorineural hearing loss and encourage neurite outgrowth towards the electrodes.
    Keywords
    polypyrrole; neurotrophin-3; brain-derived neurotrophic factor; electrical stimulation; neural engineering

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