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    Inhibition of smooth muscle cell adhesion and proliferation on heparin-doped polypyrrole

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    Author
    Stewart, EM; Liu, X; Clark, GM; Kapsa, RMI; Wallace, GG
    Date
    2012-01-01
    Source Title
    ACTA BIOMATERIALIA
    Publisher
    ELSEVIER SCI LTD
    University of Melbourne Author/s
    Kapsa, Robert; Clark, Graeme
    Metadata
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    Document Type
    Journal Article
    Citations
    Stewart, E. M., Liu, X., Clark, G. M., Kapsa, R. M. I. & Wallace, G. G. (2012). Inhibition of smooth muscle cell adhesion and proliferation on heparin-doped polypyrrole. ACTA BIOMATERIALIA, 8 (1), pp.194-200. https://doi.org/10.1016/j.actbio.2011.07.029.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33365
    DOI
    10.1016/j.actbio.2011.07.029
    Abstract
    We have investigated the application of polypyrrole (pPy) as a material to influence neointimal cell behaviour. The physico-chemical properties of pPy doped with heparin (Hep), para-toluene sulfonate, poly(2-methoxyaniline-5-sulfonic acid) (pMAS) and nitrate ions were studied in addition to cell adhesion and proliferation studies of neointimal relevant cell lines cultured on the pPy substrates. Both smooth muscle (hSMC) and endothelial (hEC) cell types adhered and proliferated best on the smooth, hydrophilic pPy/pMAS material. Moreover, pPy/Hep is able to support the proliferation of hECs on the surface but inhibits hSMC proliferation after 4 days of culture. The inhibitory effect on hSMCs is most likely due to the well-known antiproliferative effect of heparin on hSMC growth. The results presented indicate that surface exposed heparin binds to the putative heparin receptor of hSMCs and is sufficient to inhibit proliferation. The application of galvanostatically synthesized pPy/Hep to stent surfaces presents a novel bioactive control mechanism to control neointimal cell growth.
    Keywords
    restenosis; heparin; polypyrrole; smooth muscle cells

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