Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the atherosclerosis risk in communities & cardiovascular health studies
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Wong, Tien Yin; Larsen, Emily K. Marino; Klein, Ronald; MITCHELL, PAUL; Couper, David J.; Klein, Barbara E. K.; Hubbard, Larry D.; Siscovick, David S.; Sharrett, A. RicheyDate
2005Source Title
Ophthalmology: journal of the American Academy of OphthalmologyPublisher
ElsevierUniversity of Melbourne Author/s
Wong, TienAffiliation
Medicine, Dentistry and Health Sciences: Centre for Eye Research AustraliaSchool of Medicine: Ophthalmology
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Journal (Paginated)Citations
Wong, T. Y., Larsen, E. K. M., Klein, R., Mitchell, P., Couper, D. J., Klein, B. E. K., et al. (2005). Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the atherosclerosis risk in communities & cardiovascular health studies. Ophthalmology: journal of the American Academy of Ophthalmology, 112(4), 540-547.Access Status
This item is currently not available from this repositoryAbstract
Objective: To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease.
Design: Population-based cross-sectional study.
Participants: Pooled from the Atherosclerosis Risk in Communities Study (n = 12 642; mean age, 60 years) and the Cardiovascular Health Study (n = 2824; mean age, 79 years).
Methods: Retinal vein occlusion and arteriolar emboli were identified from a single nonmydriatic retinal photograph using a standardized protocol. Photographs were also graded for arteriovenous nicking and focal arteriolar narrowing. All participants had a comprehensive systemic evaluation, including standardized carotid ultrasonography.
Main Outcome Measures: Retinal vein occlusion and arteriolar emboli.
Results: Prevalences of retinal vein occlusion and arteriolar emboli were 0.3% (n = 39 cases) and 0.2% (n = 34 cases), respectively. After adjusting for age, retinal vein occlusion was associated with hypertension (odds ratio OR, 2.96; 95% confidence interval CI, 1.436.14), systolic blood pressure (BP) (OR, 4.12; 95% CI, 1.4012.16; highest quartile vs. lowest), diastolic BP (OR, 2.64; 95% CI, 1.076.46; highest quartile vs. lowest), carotid artery plaque (OR, 5.62; 95% CI, 2.6012.16), body mass index (OR, 3.88; 95% CI, 1.2312.18; highest quartile vs. lowest), plasma fibrinogen (OR, 3.29; 95% CI, 1.0810.02; highest quartile vs. lowest), arteriovenous nicking (OR, 4.09; 95% CI, 2.008.36), and focal arteriolar narrowing (OR, 5.17; 95% CI, 2.5910.29). After adjusting for age, retinal arteriolar emboli were associated with hypertension (OR, 3.14; 95% CI, 1.446.84), systolic BP (OR, 3.46; 95% CI, 1.1310.65; highest quartile vs. lowest), prevalent coronary heart disease (OR, 2.33! ; 95% CI, 1.015.42), carotid artery plaque (OR, 4.62; 95% CI, 1.8511.57), plasma lipoprotein (a) (OR, 3.6 []
Keywords
CERA; ophthalmology; Centre for Eye Research Australia; eye research; vision; visual healthExport Reference in RIS Format
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