Five-year incidence of open-angle glaucoma: the Visual Impairment Project
AuthorMukesh, Bickol N.; McCarty, Catherine A.; Rait, Julian L.; Taylor, Hugh R.
AffiliationMedicine, Dentistry and Health Sciences: Centre for Eye Research Australia
School of Medicine: Ophthalmology
Document TypeJournal (Paginated)
CitationsMukesh, B. N., McCarty, C. A., Rait, J. L. & Taylor, H. R. (2002). Five-year incidence of open-angle glaucoma: the Visual Impairment Project. Ophthalmology, 109, 1047-1051.
Access StatusThis item is currently not available from this repository
Publisher version is restricted access in accordance with the publisher's policy. The original publication is available at http://www.ncbi.nlm.nih.gov/pubmed/12045042
Purpose: To determine the incidence of open-angle glaucoma (OAG) in Melbourne, Victoria, Australia.Design: Population-based cohort study.Participants: Total of 3271 participants aged 40 years and older from Melbourne, Victoria, Australia.Main Outcome Measures: Five-year incidence of OAG. Methods: Particpants were recruited through a cluster random sampling from nine urban clusters. Baseline examination was conducted from 1992 through 1994, and the follow-up data were collected from 1997 through 1999. Each participant both at baseline and follow-up underwent a standardized ophthalmic examination including intraocular pressure measurement, visual field assessment, cup-to-disc ratio measurement, and paired stereo photographs of the optic disc. Glaucoma was assessed by a consensus group of six ophthalmologists that included two glaucoma specialists. Glaucoma was diagnosed as possible, probable, or definite. Results: The overall incidence of definite OAG was 0.5% (95% confidence limits [CL], 0.3, 0.7); probable and definite incidence of OAG was 1.1% (95%CL, 0.8, 1.4); and possible, probable, and definite OAG incidence was 2.7% (95% CL, 1.8, 3.7). The incidence of possible, probable, and definite OAG increases significantly as age increases (P<0.001). The incidence of definite OAG increases from 0% of participants aged 40 to 49 years to 4.1% of participants aged 80 years and older. The incidence of probable and definite OAG increases from 0.2% of participants 40 to 49 years to 5.4% o participants aged 80 years and older. The incidence of possible, probable, and definiete OAG increases from 0.5% of participants aged 40 to 49 years to 11% of participants aged 80 years and older. A nonsignificant but higher incidence of definite OAG among men was observed in this study when compared with women (odds ratio 2.2%; 95% CL, 0.9, 5.0). Fifty percent of the definite OAG participants were undiagnosed. Conclusion: The incidence of OAG increases significantly with age. The undiagnosed cases suggest the need to develop novel community screening strategies for glaucoma.
KeywordsCERA; ophthalmology; Centre for Eye Research Australia; eye research; vision; visual health
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