University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne School of Population and Global Health
  • Melbourne School of Population and Global Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne School of Population and Global Health
  • Melbourne School of Population and Global Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Uptake of offer to receive genetic information about BRCA1 and BRCA2 mutations in an Australian population-based study

    Thumbnail
    Download
    Uptake of offer to receive genetic information about BRCA1 and BRCA2 mutations in an Australian population-based study (545.1Kb)

    Citations
    Altmetric
    Author
    Keogh, Louise A.; Southey, Melissa C.; Maskiell, Judi; Young, Mary-Anne; Gaff, Clara L.; Kirk, Judy; Tucker, Katherine M.; Rosenthal, Doreen; McCredie, Margaret R. E.; Giles, Graham G.; ...
    Date
    2004
    Source Title
    Cancer Epidemiology, Biomarkers & Prevention
    Publisher
    American Association for Cancer Research
    University of Melbourne Author/s
    Gaff, Clara; Giles, Graham; Hopper, John; Keogh, Louise; MASKIELL, Judi; Rosenthal, Doreen; Southey, Melissa
    Affiliation
    Medicine, Dentistry and Health Sciences: Key Centre for Women's Health in Society
    Metadata
    Show full item record
    Document Type
    Journal (Paginated)
    Citations
    Keogh, L. A., Southey, M. C., Maskiell, J., Young, M., Gaff, C. L., Kirk, J., Tucker, K. M., Rosenthal, D., McCredie, M. R. E., Giles, G. G., & Hopper, J. L. (2004). Uptake of offer to receive genetic information about BRCA1 and BRCA2 mutations in an Australian population-based study. Cancer Epidemiology, Biomarkers and Prevention, 13(12), 2258-2263.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/33589
    Description

    This is a publisher's version of an article published in Cancer Epidemiology, Biomarkers & Prevention 2004 published by American Association for Cancer Research. This version is reproduced with permission from AACR. http://cebp.aacrjournals.org/

    Abstract
    Research on the utilization of genetic testing services for mutations in BRCA1 and BRCA2 has focused on women with a strong family history of breast and ovarian cancer. We conducted a population-based case-control-family study of Australian women diagnosed with invasive breast cancer before age 40 years, unselected for family history, and tested for germ line mutations in BRCA1 and BRCA2. Case subjects found to carry a deleterious mutation and their relatives who had given a research blood sample were informed by mail that the study had identified “genetic information” and were offered the opportunity to learn more. Those interested were referred to a government-funded family cancer clinic. Of 94 subjects who received the letter, 3 (3%) did not respond and 38 (40%) declined to learn their result (16 declined the referral, 10 accepted but did not attend a clinic, and 12 attended a clinic but declined testing), and 12 (13%) remain “on hold”. The remaining 41 (44%) chose to learn their result (3 of whom already knew their mutation status). There was no evidence that the decision to learn of mutation status depended on age, gender, family history, or having been diagnosed with breast cancer. Of 19 families with more than one participant, in 11 (58%) there was discordance between relatives in receiving genetic results.
    Keywords
    genetic testing; uptake; breast cancer; BRCA1; BRCA2

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Melbourne School of Population and Global Health - Research Publications [5352]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors