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    Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

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    Author
    Gainsford, T.; Willson, T. A.; METCALF, DONALD; HANDMAN, EMANUELA; McFarlane, C.; Ng, A.; STOKES, NICOLA; Alexander, W. S.; Hilton, D. J.
    Date
    1996
    Source Title
    Proceedings of the National Academy of Sciences of the United States of America
    University of Melbourne Author/s
    Ng, Ashley; Alexander, Warren; Hilton, Douglas
    Affiliation
    School of Medicine
    Metadata
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    Document Type
    Journal (Paginated)
    Citations
    Gainsford, T., Willson, T. A., Metcalf, D., Handman, E., McFarlane, C. & Ng, A. et al. (1996). Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proceedings of the National Academy of Sciences of the United States of America, 93, 14564-14568.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33605
    Description

    The publisher’s version is restricted in accordance with the National Academy of Sciences’ policy.

    Abstract
    Many cytokines exert their biological effect through members of the hemopoietin receptor family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned from human hemopoietic cell cDNA libraries various forms of the receptor that was recently shown to bind the obesity hormone, leptin. mRNAs encoding long and short forms of the human leptin receptor were found to be coex- pressed in a range of human and murine hemopoietic organs, and a subset of cells from these tissues bound leptin at the cell surface. Ectopic expression in murine BaF3 and M1 cell lines revealed that the long, but not the short, form of the leptin receptor can signal proliferation and differentiation, respectively. In cultures of murine or human marrow cells, human leptin exhibited no capacity to stimulate cell survival or proliferation, but it enhanced cytokine production and phagocytosis of Leishmania parasites by murine peritoneal macrophages. Our data provide evidence that, in addition to its role in fat regulation, leptin may also be able to regulate aspects of hemopoiesis and macrophage function.
    Keywords
    leptin; blood; hemopoietic cytokine; macrophage; Leishmania

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