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dc.contributor.authorGainsford, T.en_US
dc.contributor.authorWillson, T. A.en_US
dc.contributor.authorMETCALF, DONALDen_US
dc.contributor.authorHANDMAN, EMANUELAen_US
dc.contributor.authorMcFarlane, C.en_US
dc.contributor.authorNg, A.en_US
dc.contributor.authorSTOKES, NICOLAen_US
dc.contributor.authorAlexander, W. S.en_US
dc.contributor.authorHilton, D. J.en_US
dc.date.accessioned2014-05-22T09:35:27Z
dc.date.available2014-05-22T09:35:27Z
dc.date.issued1996en_US
dc.date.submitted2008-05-29en_US
dc.identifier.citationGainsford, T., Willson, T. A., Metcalf, D., Handman, E., McFarlane, C. & Ng, A. et al. (1996). Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proceedings of the National Academy of Sciences of the United States of America, 93, 14564-14568.en_US
dc.identifier.urihttp://hdl.handle.net/11343/33605
dc.descriptionThe publisher’s version is restricted in accordance with the National Academy of Sciences’ policy.en_US
dc.description.abstractMany cytokines exert their biological effect through members of the hemopoietin receptor family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned from human hemopoietic cell cDNA libraries various forms of the receptor that was recently shown to bind the obesity hormone, leptin. mRNAs encoding long and short forms of the human leptin receptor were found to be coex- pressed in a range of human and murine hemopoietic organs, and a subset of cells from these tissues bound leptin at the cell surface. Ectopic expression in murine BaF3 and M1 cell lines revealed that the long, but not the short, form of the leptin receptor can signal proliferation and differentiation, respectively. In cultures of murine or human marrow cells, human leptin exhibited no capacity to stimulate cell survival or proliferation, but it enhanced cytokine production and phagocytosis of Leishmania parasites by murine peritoneal macrophages. Our data provide evidence that, in addition to its role in fat regulation, leptin may also be able to regulate aspects of hemopoiesis and macrophage function.en_US
dc.formatapplication/pdfen_US
dc.languageengen_US
dc.relation.isversionofhttp://www.pnas.org/cgi/content/full/93/25/14564en_US
dc.subjectleptinen_US
dc.subjectblooden_US
dc.subjecthemopoietic cytokineen_US
dc.subjectmacrophageen_US
dc.subjectLeishmaniaen_US
dc.titleLeptin can induce proliferation, differentiation, and functional activation of hemopoietic cellsen_US
dc.typeJournal (Paginated)en_US
melbourne.peerreviewPeer Revieweden_US
melbourne.affiliationUniversity of Melbourneen_US
melbourne.affiliation.departmentSchool of Medicineen_US
melbourne.publication.statusPublisheden_US
melbourne.source.titleProceedings of the National Academy of Sciences of the United States of Americaen_US
melbourne.source.volume93en_US
melbourne.source.pages14564-14568en_US
melbourne.elementsidNA
melbourne.contributor.authorNg, Ashley
melbourne.contributor.authorAlexander, Warren
melbourne.contributor.authorHilton, Douglas
melbourne.accessrightsThis item is currently not available from this repository


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