A major goal of systems biology is to develop comprehensive, multi-scale mathematical models of physiological systems that integrate biological knowledge from the scale of molecules to the scale of tissues and organs. ...

To date, most studies of resting-state functional connectivity implicitly assume that connections remain unchanged over time. However, recent studies suggest that functional connectivity across a range of species exhibits ...

Globally, stroke is the leading cause of disability and the second leading cause of death. Management of ischemic stroke involves rapid administration of thrombolytic therapy (clot dissolving medication) for eligible ...

Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperature, vibration, pressure and muscle tension. They consist of multiple subpopulations based ...

Brain interfaces have the potential to treat traumatic and degenerative neurological conditions, which are major causes of morbidity and disability in modern society. However, despite outstanding progress and numerous ...

Mesenchymal stromal/stem cells (MSCs) have considerable potential in the fields of cell therapies, tissue engineering, and regenerative medicine. According to clinicaltrials.gov, MSCs are employed in more than 700 registered ...

Cardiomyocytes inside the heart are densely packed with parallel columns of myofibrils and mitochondria. Growing evidence indicates a strong correlation between alterations in this sub-cellular ultrastructure and the ...

Osteoporosis (OP) is a progressive bone disease characterised by significant reduction of bone mineral density (BMD) due to loss of bone matrix and changes in bone tissue properties. OP is regarded as a worldwide health ...

There is high demand for research into the innovation and development of miniaturized electronics devices for biomedical applications such as implantable medical devices (IMD), neural prostheses (NP), embedded neural ...

Progress in stem cell technologies is based on fundamental research on exploring culture conditions that improve and optimize in vitro generation of human cell types and tissues. To date, there has been significant progress ...