Biomedical Engineering - Theses
Now showing items 1-10 of 38
A bond graph approach to integrative biophysical modelling
A major goal of systems biology is to develop comprehensive, multi-scale mathematical models of physiological systems that integrate biological knowledge from the scale of molecules to the scale of tissues and organs. ...
Dynamics of functional brain connectivity in schizophrenia: machine learning models for diagnosis and prognosis
To date, most studies of resting-state functional connectivity implicitly assume that connections remain unchanged over time. However, recent studies suggest that functional connectivity across a range of species exhibits ...
Pedalling-based exercise performance and prevention of post-thrombolysis intracerebral haemorrhage in stroke patients
Globally, stroke is the leading cause of disability and the second leading cause of death. Management of ischemic stroke involves rapid administration of thrombolytic therapy (clot dissolving medication) for eligible ...
Characterization of dorsal root ganglia sensory neurons from human pluripotent stem cells and their application for developing therapies to treat Friedreich Ataxia
Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperature, vibration, pressure and muscle tension. They consist of multiple subpopulations based ...
Stent-based endovascular brain interface: characterization of recording and stimulating properties
Brain interfaces have the potential to treat traumatic and degenerative neurological conditions, which are major causes of morbidity and disability in modern society. However, despite outstanding progress and numerous ...
Improving ex-vivo expansion of mesenchymal stromal/stem cells using acellular fetal membranes
Mesenchymal stromal/stem cells (MSCs) have considerable potential in the fields of cell therapies, tissue engineering, and regenerative medicine. According to clinicaltrials.gov, MSCs are employed in more than 700 registered ...
Role of ultrastructural alterations in diabetic cardiomyopathy
Cardiomyocytes inside the heart are densely packed with parallel columns of myofibrils and mitochondria. Growing evidence indicates a strong correlation between alterations in this sub-cellular ultrastructure and the ...
Assessment of the anabolic effects of PTH drug treatment and mechanical loading on bone using high-resolution imaging and in silico modelling
Osteoporosis (OP) is a progressive bone disease characterised by significant reduction of bone mineral density (BMD) due to loss of bone matrix and changes in bone tissue properties. OP is regarded as a worldwide health ...
Ultra-low power, low-noise and small size transceiver for wearable and implantable biomedical devices and neural prosthesis
There is high demand for research into the innovation and development of miniaturized electronics devices for biomedical applications such as implantable medical devices (IMD), neural prostheses (NP), embedded neural ...
Modeling human neurogenesis in vitro using pluripotent stem cells: the evolution from 2D to 3D
Progress in stem cell technologies is based on fundamental research on exploring culture conditions that improve and optimize in vitro generation of human cell types and tissues. To date, there has been significant progress ...