• Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes 

  Meikle, PJ; Wong, G; Barlow, CK; Weir, JM; Greeve, MA; MacIntosh, GL; Almasy, L; Comuzzie, AG; Mahaney, MC; Kowalczyk, A; ... (PUBLIC LIBRARY SCIENCE, 2013-09-27)

  The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly defined. We hypothesized that a lipidomic analysis of plasma lipids ...

• Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma 

  Matthews, GM; Lefebure, M; Doyle, MA; Shortt, J; Ellul, J; Chesi, M; Banks, K-M; Vidacs, E; Faulkner, D; Atadja, P; ... (NATURE PUBLISHING GROUP, 2013-09-01)

  Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological ...

• Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance 

  Boon, J; Hoy, AJ; Stark, R; Brown, RD; Meex, RC; Henstridge, DC; Schenk, S; Meikle, PJ; Horowitz, JF; Kingwell, BA; ... (AMER DIABETES ASSOC, 2013-02-01)

  Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance in obesity, and the intracellular accumulation of the sphingolipid ceramide has been implicated in these processes. Here, ...

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