Bio21 - Research Publications
Now showing items 1-10 of 120
Gas-assisted preparation of lead iodide perovskite films consisting of a monolayer of single crystalline grains for high efficiency planar solar cells
(ELSEVIER SCIENCE BV, 2014-11-01)
The simple planar configuration of organic-inorganic hybrid perovskite solar cells produced by a solution coating process has great potential to be a low-cost and high efficiency photovoltaic technology. However planar ...
Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)
Mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene can cause early-onset familial Parkinson disease (PD). PINK1 encodes a neuroprotective protein kinase localized at the mitochondria, and ...
Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of Leucine-rich repeat kinase 2 (LRRK2)
Genetic variations of leucine-rich repeat kinase 2 (LRRK2) are the major cause of dominantly inherited Parkinson disease (PD). LRRK2 protein contains seven predicted domains: a tandem Ras-like GTPase (ROC) domain and ...
Polymerisation of a T cell epitope with an immunostimulatory C3d peptide sequence enhances antigen specific T cell responses
The complement protein C3d and C3d derived peptides that bind CD21 are known to enhance immunity to co-immunised antigens. In this study we have synthesised the minimal CD21 binding sequence of C3d (1227LYNVEA 1232) as ...
Mass spectrometric analysis of gingival crevicular fluid biomarkers can predict periodontal disease progression
Background and Objective: Gingival crevicular fluid has been suggested as a possible source of biomarkers for periodontal disease progression. This paper describes a technique for the analysis of gingival crevicular fluid ...
Protein substrates of a novel secretion system are numerous in the bacteroidetes phylum and have in common a cleavable C-Terminal secretion signal, extensive post-translational modiﬁcation, and cell-surface attachment
(American Chemical Society (ACS), 2013)
The secretion of certain proteins in Porphyromonas gingivalis is dependent on a C-terminal domain (CTD). After secretion, the CTD is cleaved prior to extensive modification of the mature protein, probably with lipopolysaccharide, ...
Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses
(Public Library of Science (PLOS), 2014)
Porphyromonas gingivalis and Treponema denticola are strongly associated with chronic periodontitis. These bacteria have been co-localized in subgingival plaque and demonstrated to exhibit symbiosis in growth in vitro and ...
Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development
(Public Library of Science (PLOS), 2013)
Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression. Porphyromonas gingivalis, Treponema denticola and ...
Putting huntingtin "aggregation" in view with windows into the cellular milieu
(Bentham Science, 2012)
Huntington's disease arises from CAG codon-repeat expansions in the Htt gene, which leads to a Htt gene product with an expanded polyglutamine (polyQ) sequence. The length of the polyQ expansion correlates with an increased ...
Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell
(American Society for Biochemistry and Molecular Biology, 2014)
Protein aggregation into intracellular inclusions is a key feature of many neurodegenerative disorders. A common theme has emerged that inappropriate selfaggregation of misfolded or mutant polypeptide sequences is detrimental ...