Bio21 - Theses
Now showing items 1-10 of 47
Structural analysis of critical interactions in the replication machinery of rabies virus
Rabies virus is a non-segmented negative sense RNA virus that causes encephalitis in humans with a 100% case fatality rate, resulting in > 61,000 deaths/year world-wide. There are currently no treatments for rabies disease, ...
Spatial and temporal surveillance of the mechanisms controlling proteome foldedness via a FRET-based biosensor
Proteostasis (protein homeostasis) is essential for keeping the proteome functional. This process controls protein synthesis, folding and degradation and involves hundreds of genes, including those encoding chaperones, to ...
The impact of proteostasis imbalance on proteome solubility
A hallmark of neurodegenerative diseases is that certain proteins abnormally aggregate into insoluble deposits. A leading hypothesis is that a breakdown in protein folding quality control mechanisms leads to the accumulation ...
It’s hip to be square: a cyclobutene diester approach to alkyl citrate natural products
This thesis features an enatiospecfic synthesis of a key alkyl citrate retron that was leveraged in the total syntheses of squalene synthase inhibitors (-)-CJ-13,982, (-)-CJ-13,981 and (-)-L-731,120 (featured in Org. Let. ...
In vivo functional characterization of nicotinic acetylcholine receptors in Drosophila melanogaster
Nicotinic acetylcholine receptors (nAChRs) are responsible for fast excitatory synaptic transmission in insect central nervous system. Their role as targets for commercial insecticides have resulted in extensive studies ...
Characterisation of the human TIM22 mitochondrial import translocase
Mitochondria are essential cellular organelles for cell viability due to their fundamental role in ATP production, programmed cell death and biosynthetic pathways. Dysfunctional mitochondria are implicated in various ...
Fitness trade-offs involved in adaptation to host plants, diapause-egg phenotypes and pesticides pressure in the redlegged earth mite, Halotydeus destructor
The redlegged earth mite, Halotydeus destructor, is an invasive species introduced into Australia from South Africa. In Australia, this species enters summer diapause at the egg stage which can survive desiccation, heat ...
Synthesis and kinetics of novel ionic liquid soluble hydrogen atom transfer reagents
The use of radical methodologies has been greatly developed in the last 50 years, and in an effort to continue this progress, the reactivity of radical reactions in greener alternative solvents is desired. The work herein ...
Genetic epidemiology of the Plasmodium falciparum reservoir of infection in Bongo District, Ghana
Malaria remains a major global health problem, with Plasmodium falciparum being the causative agent of the majority of malaria-related deaths and clinical cases in humans. This burden is largely concentrated in West and ...
Structural basis of the interaction between the C-terminal domain of rabies virus phosphoprotein and human STAT1
The archetype rabies virus belongs to the genus lyssavirus which collectively are the causative agents of rabies disease. The deadly disease has a 100% case-fatality rate in humans, killing over 61,000 people a year and ...