Bio21 - Theses
Now showing items 1-10 of 51
Deciphering the signalling pathways associated with neuronal death in excitotoxicity by quantitative proteomic approaches
Excitotoxicity is a primary pathological process directing neuronal cell death in both acute neurological disorders and neurodegenerative diseases such as ischemic stroke and Alzheimer’s disease. It is initiated by ...
The oxidative damage of biological molecules by air pollutants NO2● and NO3●
Air pollution is perceived as the world’s greatest environmental risk to human health. According to the World Health Organization (WHO), air pollution is responsible for the deaths of about 7 million people each year. In ...
Investigating the metabolic regulation capacity of the malaria parasite P. falciparum
The pathogenic stages of the malaria parasite Plasmodium falciparum develop within red blood cells, where they have access to an abundant supply of glucose. Unsurprisingly, these parasite stages are heavily reliant upon ...
Investigation of the mechanisms of action of and resistance to artemisinin and other endoperoxide antimalarials
P. falciparum malaria caused 219 million cases with an estimation of 435,000 deaths in 2017. Artemisinin (ART) combination therapies (ACTs) reduce the parasite load swiftly and have contributed to decreasing malaria deaths. ...
Structural analysis of critical interactions in the replication machinery of rabies virus
Rabies virus is a non-segmented negative sense RNA virus that causes encephalitis in humans with a 100% case fatality rate, resulting in > 61,000 deaths/year world-wide. There are currently no treatments for rabies disease, ...
Spatial and temporal surveillance of the mechanisms controlling proteome foldedness via a FRET-based biosensor
Proteostasis (protein homeostasis) is essential for keeping the proteome functional. This process controls protein synthesis, folding and degradation and involves hundreds of genes, including those encoding chaperones, to ...
The impact of proteostasis imbalance on proteome solubility
A hallmark of neurodegenerative diseases is that certain proteins abnormally aggregate into insoluble deposits. A leading hypothesis is that a breakdown in protein folding quality control mechanisms leads to the accumulation ...
It’s hip to be square: a cyclobutene diester approach to alkyl citrate natural products
This thesis features an enatiospecfic synthesis of a key alkyl citrate retron that was leveraged in the total syntheses of squalene synthase inhibitors (-)-CJ-13,982, (-)-CJ-13,981 and (-)-L-731,120 (featured in Org. Let. ...
In vivo functional characterization of nicotinic acetylcholine receptors in Drosophila melanogaster
Nicotinic acetylcholine receptors (nAChRs) are responsible for fast excitatory synaptic transmission in insect central nervous system. Their role as targets for commercial insecticides have resulted in extensive studies ...
Characterisation of the human TIM22 mitochondrial import translocase
Mitochondria are essential cellular organelles for cell viability due to their fundamental role in ATP production, programmed cell death and biosynthetic pathways. Dysfunctional mitochondria are implicated in various ...