Chancellery Research - Research Publications
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ItemEvidence that superstructures comprise self-similar coherent motions in high Reynolds number boundary layers(Cambridge University Press, 2023-08-11)We present experimental evidence that the superstructures in turbulent boundary layers comprise smaller, geometrically self-similar coherent motions. The evidence comes from identifying and analysing instantaneous superstructures from large-scale particle image velocimetry datasets acquired at high Reynolds numbers, capable of capturing streamwise elongated motions extending up to 12 times the boundary layer thickness. Given the challenge in identifying the constituent motions of the superstructures based on streamwise velocity signatures, a new approach is adopted that analyses the wall-normal velocity fluctuations within these very long motions, which reveals the constituent motions unambiguously. The conditional streamwise energy spectra of the Reynolds shear stress and the wall-normal fluctuations, corresponding exclusively to the superstructure region, are found to exhibit the well-known distance-from-the-wall scaling in the intermediate-scale range. It suggests that geometrically self-similar motions are the constituent motions of these very-large-scale structures. Investigation of the spatial organization of the wall-normal momentum-carrying eddies, within the superstructures, also lends empirical support to the concatenation hypothesis for the formation of these structures. The association between the superstructures and self-similar motions is reaffirmed on comparing the vertical coherence of the Reynolds-shear-stress-carrying motions, by computing conditionally averaged two-point correlations, which are found to match with the mean correlations. The mean vertical coherence of these motions, investigated for the log region across three decades of Reynolds numbers, exhibits a unique distance-from-the-wall scaling invariant with Reynolds number. The findings support modelling of these dynamically significant motions via data-driven coherent structure-based models.
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ItemEncountering a Pedagogy of the World in a University Setting(Taylor & Francis, 2021)Taking up Biesta’s (2019) notion of a pedagogy of the world, we ask: How might participating in an arts-based educational program with/in a university enable young people from schools with low Index of Community Socio-Educational Advantage (ICSEA) values to encounter the world of higher education differently and become different in that encounter? This chapter comes from our engagement with empirical material generated during a (post)qualitative inquiry into the pedagogy of The Art of Engagement-a multi-arts studio program involving relational pedagogy and a/r/tography as curriculum located in SPACE, 1 whereby secondary school students from schools in less socio-educationally advantaged communities came together with undergraduate university students for a five-day intensive within a University of Melbourne breadth subject. The program’s rationale was to connect with secondary school arts students completing their schooling in lower ICSEA value schools 2 through the design of authentic university encounters with/in site, practices and communities. It welcomed the secondary school students into the world of our university and enhanced their capacity to “be at home” in this world, creating the conditions for considering and potentially living different post-school futures.
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ItemScicurious as method: Learning from GLAM young people living in a pandemic about cultivating digital co-research-creation spaces that ignite curiosity and creativity(Bristol University Press, 2020-10-23)Could COVID-19, this unexpected crisis, act as a comma in a co-research-creation project to become a breathing space and not a full stop? Maybe this pause is a colon: the two different periods of the project (and life in general) on either side of the pandemic, equally important and dependent on each other for full meaning. In this chapter, we tell the story of how a co-research-creation event (the Sci Curious Project) unfolded before and during the COVID-19 pandemic; the lead-up to its irruption (St. Pierre, 1997) and then what came after. ‘Scicurious as method’ emerged out of the unexpected pause and recalibration of the project; a method that emphasizes the creation of research spaces that activate scicuriosity in situated practice. We understand scicuriosity as emerging from collaborative research-creation events that ignite curiosity and creativity. Scicurious as method is presented through an encounter with speculative fiction and scicurious zine travels. Scicurious as method has significant ethical implications, these reify the potential of co-designed speculative inquiries with creativity and curiosity at their heart. This is, in part, due to its contingency on cultivating digital co-research-creation spaces that enfold rather than eschew the analogue and highlight the joyous potential of a deeply situated, co-designed speculative inquiry; an inquiry with galleries, libraries, archives and museums (GLAM) young people living in a pandemic.
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ItemNo Preview AvailableCognition in healthy older women is a predictor of 14‐year falls risk(Wiley, 2021-12)Background: Falls are a significant cause of injuries, loss of confidence, increased morbidity, and institutionalisation in all older people, with women at 50% greater risk than men. The relationship between dementia and falls is well established and 2/3 of all dementia occurs in women. In this study we explored risk factors associated with a 14 year falls risk in a community-based cohort of women, which included validated measures across a wide range of clinical domains including neuropsychological, mood, quality of life and biomarkers (including hormonal). Method: The Australian Women’s Healthy Aging Project is an longitudinal observation study, assessments every year (1991 –1999), followed by assessments in 2002, 2004, 2012 and 2014. The assessments included cognitive (as of 2002), blood, and cardiovascular disease risk assessment, and questions related to falls. After data cleaning, the remaining cohort consisted of 180 participants (Table 1). Missing data were imputed using mice random forest. To identify key risk factors associated with a 14 year falls risk, random survival (time to event) forest (RSF) machine learning was used. Result: The RSF model, using all 290+ possible predictive variables, performed well with an Out Of Bag (OOB, withheld data) prediction error (C-index) of 32.8%. The most predictive variables in the model were identified using the variable importance measure (VIM). The initial model was refined by taking the top 30 predictive variables and retraining the RSF. This refined model resulted in an improved OOB C-index of 5.8% (27%). The top 20 predictive variables, Figure 1, include those associated with cardiovascular disease risk, cognitive performance, and hormone levels (e.g., family history of heart attack, digit symbol coding, and estradiol levels). Conclusion: Ninety percent of the top 20 predictive risk variables for the 14 year fall risk in women, were from three key domains, cognition (40%), cardiovascular (25%) and hormone-related measurements (25%). Our data suggest that for long term prevention of falls these domains may be important reducing risk of falls in the senior female population.
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ItemThe establishment of a cytomegalovirus -specific CD8(+) T-cell threshold by kinetic modeling for the prediction of post-hemopoietic stem cell transplant reactivation(CELL PRESS, 2022-10-26)The dynamic interaction between the CMV virus and host immune response remains obscure, thus hindering the diagnosis and therapeutic management of patients with HSCT. The current diagnosis of CMV viremia depends on viral load estimation. Medical intervention based on viral load, can be unnecessary or poorly timed for many patients. Here we examined the clinical features and blood samples of patients with HSCT and assessed the CMV reactivation kinetics and corresponding CMV antigen-specific T-cell response in individual patients based on a peptide pool stimulation T-cell assay, which showed that CMV-specific CD8+ T cells were more suitable to be a diagnosis indicator for suppressing CMV reactivation. Using ROC analysis, we defined and verified a CMV-specific CD8+ T-cell counts threshold (925 cells/106 PBMCs) as an indicator of CMV reactivation post-HSCT, and suggested that use of this threshold would provide more accurate guidance for prompt medication and better management of CMV infection post-HSCT.
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ItemNo Preview AvailableDual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation(AMER ASSOC IMMUNOLOGISTS, 2022-03-15)Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT cells have an invariant TCRα-chain that uses T cell receptor α-variable 1-2 (TRAV1-2) joined to TRAJ33/20/12 and recognizes metabolites from bacterial riboflavin synthesis bound to the Ag-presenting molecule MHC class I related (MR1). Our attempts to identify alternative MR1-presented Ags led to the discovery of rare MR1-restricted T cells with non-TRAV1-2 TCRs. Because altered Ag specificity likely alters affinity for the most potent known Ag, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), we performed bulk TCRα- and TCRβ-chain sequencing and single-cell-based paired TCR sequencing on T cells that bound the MR1-5-OP-RU tetramer with differing intensities. Bulk sequencing showed that use of V genes other than TRAV1-2 was enriched among MR1-5-OP-RU tetramerlow cells. Although we initially interpreted these as diverse MR1-restricted TCRs, single-cell TCR sequencing revealed that cells expressing atypical TCRα-chains also coexpressed an invariant MAIT TCRα-chain. Transfection of each non-TRAV1-2 TCRα-chain with the TCRβ-chain from the same cell demonstrated that the non-TRAV1-2 TCR did not bind the MR1-5-OP-RU tetramer. Thus, dual TCRα-chain expression in human T cells and competition for the endogenous β-chain explains the existence of some MR1-5-OP-RU tetramerlow T cells. The discovery of simultaneous expression of canonical and noncanonical TCRs on the same T cell means that claims of roles for non-TRAV1-2 TCR in MR1 response must be validated by TCR transfer-based confirmation of Ag specificity.
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ItemNo Preview AvailableInvestigation of the Extraction of Natural Alkaloids in Karr Reciprocating Hate Columns: Mass Transfer Study(TAYLOR & FRANCIS INC, 2022-09-18)
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ItemNo Preview AvailableCollaborative Development of Polymer-Based Collection Survey Methodology and Relational Data Model(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2022-03-15)
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ItemNo Preview AvailableMapping the spatial politics of Australian settler colonialism(ELSEVIER SCI LTD, 2023-03-10)