Melanoma is an aggressive cancer with extremely unfavourable prognosis. Two main types of melanoma include cutaneous melanoma (CM) accounting for around 95% and uveal melanoma (UM) around 5%. In Australia, melanoma is in ...

The standard of care for locally advanced rectal cancer (T3-4 +/- N+) is neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME). However, this has been challenged recently with increasing interest ...

Targeting non-transformed stromal components of the tumour microenvironment (TME) has become clinically attractive in treating cancer over the last few decades. On this basis, vascular endothelial growth factor A (VEGFA) ...

Cancer progression is invariably associated with changes in the stromal microenvironment, most notably, the extracellular matrix (ECM) composition. Laminins (LM) are a family of large trimeric ECM proteins comprised of at ...

Adoptive cell therapy using chimeric antigen receptor (CAR) T cells has shown great success in haematological malignancies, leading to recent approval of two CD19-specific CAR T cell products by the Food and Drug Administration ...

Recent studies by our group and others have demonstrated that oncogene- driven hyper-activation of ribosome synthesis and activity is a vulnerability that can be targeted for cancer treatment. Specifically, combined ...

All biological systems follow the rules and constraints imposed during their evolution. Current-day gene phenotypes such as gene expression, gene essentiality, gene function and protein localization are linked with the ...

In 2007, the concept of rapid learning healthcare was proposed in the United States of America health system in a response to increasing healthcare costs. Its aim was to accelerate knowledge discovery through a systematic ...

Head and neck squamous cell carcinoma (HNSCC) is a genetically heterogeneous cancer with poor prognosis. Current treatments for HNSCC are ineffective, and the resistance to therapies is often associated with a prominent ...

Advances in genomic sequencing have improved clinical outcomes in patients with haematological malignancies by allowing more refined diagnostic and prognostic stratification. However, significant challenges still remain ...