Sir Peter MacCallum Department of Oncology - Theses
Now showing items 1-10 of 45
Genotypic phenotypic correlation in male breast cancer
Male breast cancers (MBCs) are rare cancers, comprising less than 1% of all breast cancers and less than 1% of all cancers in men. As a result, these cancers have not been well characterized with almost all management ...
Pre-clinical assessment of the co-operative effects of Trastuzumab and Panobinostat in HER2 overexpressing breast cancer
The introduction of Trastuzumab (Herceptin®)-based chemotherapy combinations into standard clinical practice has revolutionized the treatment of human epidermal growth factor receptor 2-positive (HER2+) breast cancer. ...
Profiling desmoid tumours and exploring new strategies to prevent and treat desmoid tumours in familial adenomatous polyposis using a novel mouse model
Desmoid tumour is a benign growth that causes morbidity and mortality from local enlargement. Desmoids are thought to result from dysfunction in WNT signalling. Trauma, including that from surgical intervention, is ...
Investigating acquired resistance to Pol I transcription inhibitors for the treatment of haematologic malignancies
Previous work from our group and others has demonstrated that CX-5461 (Senhwa Biosciences), a first-in-class small molecule inhibitor of RNA Polymerase I transcription of the ribosomal RNA genes, is effective at treating ...
Fever and neutropenia in children with cancer: optimising clinical research and the delivery of care in Australia
Fever and neutropenia (FN) is the most common complication of childhood cancer treatment. Management traditionally involves hospital admission for antibiotics until resolution of fever and recovery of neutrophil count. ...
Targeting cyclin dependent kinase 4 (CDK4) in melanoma: mechanisms of resistance and novel combination therapies
Activation of the Cyclin-Dependent Kinase 4 (CDK4) pathway is a frequent occurrence in cancer and is a major risk factor for the development of melanoma. Activation of this pathway occurs predominantly as a result of ...
Pragmatic, consensus-based minimum standards and structured interview to guide the selection and development of cancer support group leaders
Across the globe, peer support groups have emerged as a community-led approach to connecting people with cancer experiences and accessing support. Members of cancer support groups seek to help themselves and each other ...
Detection and characterisation of prostate cancer from multiparametric MRI using machine learning techniques
Prostate cancer (PCa) is the most commonly diagnosed cancer type in males in Australia and radiotherapy provides an efficacious treatment option. However, traditional approaches of radiotherapy apply a uniform high radiation ...
Restoration of tumour suppression in prostate cancer
Aberration in signalling pathways due to the overexpression of oncogenes, and/or loss or mutations in tumour suppressors are key events during carcinogenesis. Hence, novel approaches to target oncogenes in order to restore ...
The impact of sex differences on host and tumour prognostic factors in patients with non-small cell lung cancer
Epidemiological studies demonstrate that women live longer than men following diagnosis of non-small cell lung cancer (NSCLC) even after controlling for prognostic factors. This study examines the one biological trait all ...