Sir Peter MacCallum Department of Oncology - Theses
Now showing items 1-10 of 72
Understanding and manipulating epigenetics in cancer
The appropriate regulation of gene expression programs is essential for normal cellular function. In cancer, mutations derail normal developmental gene expression programs resulting in a malignant epigenetic state. ...
Overcoming Tumour Resistance to Adoptive Immunotherapy by Enhancing CTL function
While adoptive cell transfer (ACT) therapy using chimeric antigen receptor (CAR) T cells can be effective in the treatment of haematological B cell malignancies, the treatment of solid tumours has been challenging. Limiting ...
Uncovering a role for RYK, a WNT-binding receptor tyrosine kinase, in cancer
Cancer is the leading cause of disease burden in Australia. Targeted therapy utilises oncogenic mutations in tumours by modulating cancer-promoting proteins and signalling pathways. While these drugs deliver promising ...
Identification and molecular characterisation of high-risk pre-malignant breast lesions
Mammographic screening has led to an increased detection of in situ and invasive breast carcinoma. However, lesions with uncertain malignant potential (B3) are also frequently detected with routine mammographic screening. ...
A Genome-wide RNAi screen identifies combinatorial efficacy of CX-5461 with homologous recombination deficiency and Topoisomerase I inhibition in ovarian cancer
High-grade serous ovarian cancer (HGSC) is common, with poor prognosis. Limited therapeutic options are available, and the development of new therapies is of high priority. The RNA Polymerase I (Pol I) transcription inhibitor ...
The development, validation and application of novel preclinical models for the study of Barrett's carcinogenesis
Oesophageal adenocarcinoma is an aggressive malignancy and is associated with extremely poor rates of survival. Its only known precursor is Barrett’s oesophagus, which is a metaplasia that occurs in the lower oesophagus ...
Novel combination therapies with the RNA Polymerase I-mediated transcription inhibitor CX-5461 improve efficacy in the treatment of multiple myeloma
Multiple myeloma (MM) is a malignant plasma cell disorder that is incurable with currently available therapy. The disease is genetically heterogeneous, with many recurrently mutated genes only seen in small numbers of ...
Identification and validation of novel breast cancer predisposition genes
The genetic causes of the majority of hereditary breast cancer families remain unresolved (BRCAx families) and lack of this information compromises primary and secondary cancer prevention for the affected women and their ...
Investigating the innate and adaptive immune response in patients with metastatic colorectal cancer
The immune response is strongly associated with outcome in CRC (stages I-III). Cytotoxic CD8+ T-cells are the most important subset of immune cells positively associated with outcome, in most solid malignancies and especially ...
Exploration of novel regulators of mutant p53 in cancer cells: a role for NDFIP1
Mutations in the tumour suppressor gene, TP53 occur in more than 50% of human cancers. Mutant p53 proteins not only lose their tumour suppressive capacities, but also gain oncogenic functions, broadly referred to as gain ...