Sir Peter MacCallum Department of Oncology - Theses
Now showing items 1-10 of 63
Exploration of novel regulators of mutant p53 in cancer cells: a role for NDFIP1
Mutations in the tumour suppressor gene, TP53 occur in more than 50% of human cancers. Mutant p53 proteins not only lose their tumour suppressive capacities, but also gain oncogenic functions, broadly referred to as gain ...
Role of rDNA chromatin in sensitizing OVCA to RNA polymerase I transcription inhibitors
The ribosomal RNA (rRNA) genes (rDNA) are arrayed in multiple tandem repeats on the 5 acrocentric chromosomes, and are transcribed by RNA Polymerase I (Pol I) which gives rise to the 47S pre-rRNA, the precursor of 18S, ...
Investigating the role of the Ras/MAPK pathway in increasing immunogenicity of triple negative breast cancers
The predictive and prognostic significance of tumour infiltrating lymphocytes (TILs) has been highlighted in various solid cancers in recent years, where TIL infiltration has become a landmark biomarker of survival outcomes ...
Investigating epigenetic perturbations associated with DNMT3A and BCOR mutations in normal and malignant haematopoiesis
Despite recent advances in cancer detection, molecular classification and treatment modalities, the 5-year survival rate of acute myeloid leukaemia (AML) has not changed in 30 years. The unique genetic context created by ...
Defining resistance mechanisms and clonal dynamics in mantle cell lymphoma treated with novel targeted therapies
Mantle cell lymphoma (MCL) is a B-cell malignancy and often an incurable disease. Novel targeted therapeutics are poised to significantly change the natural history of this disease. The combination of ibrutinib and venetoclax ...
Identification and characterisation of novel mutant p53 regulators
The p53 protein is a transcription factor and has been considered as a master tumour suppressor. TP53 gene is frequently mutated in human cancers (more than 50%). Mutation in p53 not only loses its tumour suppressive ...
Investigating the nucleolar stress response and targets that modulate p53 activation
The nucleolus is a multifunctional organelle known as the central hub for ribosome biogenesis. Now, it is widely accepted that nucleolus also serves non-canonical role as a stress sensor, responding to numerous internal ...
Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies
A prominent theme in malignant transformation is abnormal regulation of epigenetic processes that facilitate gene expression profiles underpinning malignant initiation and progression. The plasticity of the epigenome lends ...
The control of melanoma by the Hippo pathway
Melanoma is an aggressive cancer with extremely unfavourable prognosis. Two main types of melanoma include cutaneous melanoma (CM) accounting for around 95% and uveal melanoma (UM) around 5%. In Australia, melanoma is in ...
Immune markers to predict response to neoadjuvant chemoradiotherapy and identifying methods to incorporate immunotherapy in locally advanced rectal cancer
The standard of care for locally advanced rectal cancer (T3-4 +/- N+) is neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME). However, this has been challenged recently with increasing interest ...