Can we detect altered disease state in early stage Huntington’s Disease using acoustic markers of speech?
AuthorVogel, A. P.; Shirbin, C.; Churchyard, A. J.; Stout, J. C.
Source TitleProceedings of the 14th Australasian International Conference on Speech Science and Technology
University of Melbourne Author/sVogel, Adam
AffiliationDepartment of Audiology and Speech Pathology
Audiology and Speech Pathology
Document TypeConference Paper
CitationsVogel, A. P., Shirbin, C., Churchyard, A. J. & Stout, J. C. (2012). Can we detect altered disease state in early stage Huntington’s Disease using acoustic markers of speech? In Proceedings of the 14th Australasian International Conference on Speech Science and Technology, Sydney, Australia.
Access StatusThis item is currently not available from this repository
© 2012 ASSTA
Altered prosody has been described in symptomatic Huntington’s Disease (HD) individuals, however, the extent to which acoustic analysis of speech is sensitive to gene positive pre-manifest (PreHD) individuals is unknown. Speech samples were acquired from 30 individuals carrying the mutant HTT gene (13 PreHD, 17 early stage HD) and 15 matched controls. Participants read a passage, produced a monologue, counted from 1-20 and said the days of the week. Data were analysed acoustically for measures of timing, frequency and intensity. Tasks were compared to determine their relative sensitivity to disease state. Tasks with greater cognitive demand appeared more suitable for detecting Huntington’s disease compared to tasks with high levels of automaticity.
Keywordsacoustic analysis; clinical marker; Huntington’s disease
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References