A bio-informatics study of the c25 cysteine protease family

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    Author
    Cross, K. J.; Huq, N. L.; Reynolds, E. C.
    Date
    2012
    Source Title
    Open Journal of Genetics
    Publisher
    Scientific Research
    University of Melbourne Author/s
    Cross, Keith; Huq, Laila; Reynolds, Eric
    Affiliation
    Oral Health CRC, Melbourne Dental School
    Bio21 Institute
    Bio21
    Melbourne Dental School
    Metadata
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    Document Type
    Journal Article
    Citations
    Cross, K. J., Huq, N. L., & Reynolds, E. C. (2012). A bio-informatics study of the c25 cysteine protease family. Open Journal of Genetics, 2(4B), 18-22.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/39669
    DOI
    10.4236/ojgen.2012.24B004
    NHMRC Grant code
    NHMRC/1029878
    Description

    Published Version

     

    Copyright © 2012 SciRes.

     

    The research outputs in this collection have been funded in whole or in part by the National Health and Medical Research Council (NHMRC)

     
    Abstract
    The oral pathogen Porphyromonas gingivalis is recognized as one of the major aetiological agents of chronic periodontitis. The gingipains, which are the principal virulence factors of P. gingivalis, are multi-domain proteins containing an N-terminal C25 cysteine protease domain. We have conducted a bio-informatics study of the C25 cysteine protease domains and have identified related domains in over two thousand proteins from 739 organisms in 35 distinct phyla. Proteins having significant similarity to the gingipain C25 cysteine protease domain are also found in Gram +ve bacteria, Archaea, algae, higher fungi, and a wide variety of Eukaryotic species.
    Keywords
    c25 cysteine proteases; evolution; substrate preference

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