Increased susceptibility to injury in older eyes
AuthorCharng, Jason; Nguyen, Christine T. O.; Vingrys, Algis J.; Jobling, Andrew I.; Bui, Bang V.
Source TitleOptometry and Vision Science
PublisherLippincott Williams & Wilkins
University of Melbourne Author/sCharng, Jason; Nguyen, Christine; Vingrys, Algis; Jobling, Andrew; Bui, Bang
AffiliationDepartment of Optometry and Vision Sciences
Optometry and Vision Sciences
Document TypeJournal Article
CitationsCharng, J., Nguyen, C. T. O., Vingrys, A. J., Jobling, A. I. & Bui, B. V. (2013). Increased susceptibility to injury in older eyes. Optometry and Vision Science, 90(3), 275–281.
Access StatusOpen Access
NHMRC Grant codeNHMRC/535077
© 2013 American Academy of Optometry
The research outputs in this collection have been funded in whole or in part by the National Health and Medical Research Council (NHMRC)
Purpose: To determine whether there is an age-dependent susceptibility in retinal function in response to repeated anterior chamber cannulation with or without intraocular pressure (IOP) elevation. Methods: Baseline electroretinograms were measured in 3- and 18-month-old Sprague-Dawley rats (n = 16 each group). Following baseline assessment, eyes were randomly assigned to undergo a 60-min anterior chamber cannulation with IOP either left at baseline (sham, 15 mm Hg) or elevated to 60 mm Hg. This was repeated three additional times, with each episode separated by 1 week. At weeks 1 to 3, dark-adapted retinal function was assessed immediately before cannulation, with final functional assessment at week 4. Results: Both sham and IOP elevated eyes of older rats showed retinal dysfunction, which became more pronounced with the number of repeated insults. This effect was largest for responses arising from the inner retina. Repeated insult in younger eyes did not produce a change in amplitude but an increase in the sensitivity to light of photoreceptoral and bipolar cell components of the electroretinogram. Conclusions: Repeated trauma, not IOP, produces permanent retinal dysfunction in older eyes. Younger eyes appear to be able to withstand this type of injury by upregulating sensitivity of outer and middle retinal responses to maintain normal inner retinal function.
Keywordsaging; electroretinogram; rat; intraocular pressure; retina
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References