The Role of the Apoptotic Machinery in Tumor Suppression
AuthorDelbridge, Alex R. D.; Valente, Liz J.; Strasser, Andreas
Source TitleCOLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
PublisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
AffiliationSir Peter MacCallum Department of Oncology
Document TypeJournal Article
Access StatusThis item is currently not available from this repository
NHMRC Grant codeNHMRC/466658
Fulltext embargoed for: 18 months post date of publication
Multicellular organisms have evolved processes to prevent abnormal proliferation or inappropriate tissue infiltration of cells, and these tumor suppressive mechanisms serve to prevent tissue hyperplasia, tumor development, and metastatic spread of tumors. These include potentially reversible processes such as cell cycle arrest and cellular senescence, as well as apoptotic cell death, which in contrast eliminates dangerous cells that may initiate tumor development. Tumor suppressive processes are organized as complex, extensive signaling networks, controlled by central "nodes." These "nodes" are prominent tumor suppressors, such as P53 or PTEN, whose loss is responsible for the development of the majority of human cancers. In this review we discuss the processes by which some of these prominent tumor suppressors trigger apoptotic cell death and how this process protects us from cancer development.
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