Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: Testing the evidence for an endophenotypic marker
AuthorBrewer, Warrick J.; Lin, Ashleigh; Moberg, Paul J.; Smutzer, Gregory; Nelson, Barnaby; Yung, Alison R.; Pantelis, Christos; McGorry, Patrick D.; Turetsky, Bruce I.; Wood, Stephen J.
Source TitlePSYCHIATRY RESEARCH
University of Melbourne Author/sBrewer, Warrick; LIN, ASHLEIGH; Nelson, Barnaby; Yung, Alison; Pantelis, Christos; McGorry, Patrick; Wood, Stephen
AffiliationCentre for Youth Mental Health
Document TypeJournal Article
Access StatusThis item is currently not available from this repository
The fulltext of this publication will be made publicly available after relevant embargo periods have lapsed and associated copyright clearances obtained.
Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to controls have recently been controversial. If supported, a genetic-based phenotypic variation in PTC taster status is implicated, suggesting a greater illness risk for those participants with recessive alleles for the TAS2R38 receptor. Should PTC insensitivity be a schizophrenia endophenotype, then it would be expected in follow-up of ultra high-risk for psychosis participants who later develop schizophrenia (UHR-S). UHR-S was hypothesised to show reduced PTC sensitivity compared to those who were previously at risk, but did not transition (UHR-NP). PTC perception was assessed in 219 UHR participants at long-term follow-up, of whom 53 had transitioned to psychosis (UHR-P) during the follow-up period. Fifteen of the 219 participants were diagnosed with schizophrenia. Seventy-eight had a family history of psychotic disorder. No differences in PTC taster status were found in UHR participants based upon transition to psychosis status, schizophrenia diagnosis, or family history of schizophrenia. This report indicates that schizophrenia development among UHR participants is not associated with PTC tasting deficits and fails to support previous findings that inability to detect the bitter taste of PTC is a schizophrenia endophenotype.
KeywordsTaste; Endophenotype; Prediction; Mental illness; Psychosis; Risk
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