11q13 is a susceptibility locus for hormone receptor positive breast cancer
AuthorLambrechts, D; Truong, T; Justenhoven, C; Humphreys, MK; Wang, J; Hopper, JL; Dite, GS; Apicella, C; Southey, MC; Schmidt, MK; ...
Source TitleHUMAN MUTATION
University of Melbourne Author/sAPICELLA, CARMEL; Hopper, John; Baglietto, Laura; Dite, Gillian; Milne, Roger; Giles, Graham; Southey, Melissa; Severi, Gianluca
AffiliationMelbourne Students & Learning
Document TypeJournal Article
CitationsLambrechts, D; Truong, T; Justenhoven, C; Humphreys, MK; Wang, J; Hopper, JL; Dite, GS; Apicella, C; Southey, MC; Schmidt, MK; Broeks, A; Cornelissen, S; van Hien, R; Sawyer, E; Tomlinson, I; Kerin, M; Miller, N; Milne, RL; Pilar Zamora, M; Arias Perez, JI; Benitez, J; Hamann, U; Ko, Y-D; Bruening, T; Chang-Claude, J; Eilber, U; Hein, R; Nickels, S; Flesch-Janys, D; Wang-Gohrke, S; John, EM; Miron, A; Winqvist, R; Pylkas, K; Jukkola-Vuorinen, A; Grip, M; Chenevix-Trench, G; Beesley, J; Chen, X; Menegaux, F; Cordina-Duverger, E; Shen, C-Y; Yu, J-C; Wu, P-E; Hou, M-F; Andrulis, IL; Selander, T; Glendon, G; Mulligan, AM; Anton-Culver, H; Ziogas, A; Muir, KR; Lophatananon, A; Rattanamongkongul, S; Puttawibul, P; Jones, M; Orr, N; Ashworth, A; Swerdlow, A; Severi, G; Baglietto, L; Giles, G; Southey, M; Marme, F; Schneeweiss, A; Sohn, C; Burwinkel, B; Yesilyurt, BT; Neven, P; Paridaens, R; Wildiers, H; Brenner, H; Mueller, H; Arndt, V; Stegmaier, C; Meindl, A; Schott, S; Bartram, CR; Schmutzler, RK; Cox, A; Brock, IW; Elliott, G; Cross, SS; Fasching, PA; Schulz-Wendtland, R; Ekici, AB; Beckmann, MW; Fletcher, O; Johnson, N; Silva, IDS; Peto, J; Nevanlinna, H; Muranen, TA; Aittomaki, K; Blomqvist, C; Doerk, T; Schuermann, P; Bremer, M; Hillemanns, P; Bogdanova, NV; Antonenkova, NN; Rogov, YI; Karstens, JH; Khusnutdinova, E; Bermisheva, M; Prokofieva, D; Gancev, S; Jakubowska, A; Lubinski, J; Jaworska, K; Durda, K; Nordestgaard, BG; Bojesen, SE; Lanng, C; Mannermaa, A; Kataja, V; Kosma, V-M; Hartikainen, JM; Radice, P; Peterlongo, P; Manoukian, S; Bernard, L; Couch, FJ; Olson, JE; Wang, X; Fredericksen, Z; Alnaes, GG; Kristensen, V; Borresen-Dale, A-L; Devilee, P; Tollenaar, RAEM; Seynaeve, CM; Hooning, MJ; Garcia-Closas, M; Chanock, SJ; Lissowska, J; Sherman, ME; Hall, P; Liu, J; Czene, K; Kang, D; Yoo, K-Y; Noh, D-Y; Lindblom, A; Margolin, S; Dunning, AM; Pharoah, PDP; Easton, DF; Guenel, P; Brauch, H, 11q13 is a susceptibility locus for hormone receptor positive breast cancer, HUMAN MUTATION, 2012, 33 (7), pp. 1123 - 1132
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370081
The fulltext of this publication will be made publicly available after relevant embargo periods have lapsed and associated copyright clearances obtained.
A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ≤ 3 × 10(-9) ) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10(-39) ). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.
Keywordsbreast cancer susceptibility; polymorphisms; genome-wide association; risk factors; hormone receptor status; 11q13
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References