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dc.contributor.authorMasaoka, Yuri
dc.contributor.authorHarding, Ian H.
dc.contributor.authorKoiwa, Nobuyoshi
dc.contributor.authorYoshida, Masaki
dc.contributor.authorHarrison, Ben J.
dc.contributor.authorLorenzetti, Valentina
dc.contributor.authorIda, Masahiro
dc.contributor.authorIzumizaki, Masahiko
dc.contributor.authorPantelis, Christos
dc.contributor.authorHomma, Ikuo
dc.date.accessioned2014-08-26T04:22:09Z
dc.date.available2014-08-26T04:22:09Z
dc.date.issued2014-06-25
dc.identifier.issn1569-9048
dc.identifier.urihttp://hdl.handle.net/11343/41996
dc.description.abstractOlfaction is dependent on respiration for the delivery of odorants to the nasal cavity. Taking advantage of the time-locked nature of inspiration and olfactory processing, electroencephalogram dipole modeling (EEG/DT) has previously been used to identify a cascade of inspiration-triggered neural activity moving from primary limbic olfactory regions to frontal cortical areas during odor perception. In this study, we leverage the spatial resolution of functional magnetic resonance imaging (fMRI) alongside the temporal resolution of EEG to replicate and extend these findings. Brain activation identified by both modalities converged within association regions of the orbitofrontal cortex that were activated from approximately 150-300 ms after inspiration onset. EEG/DT was additionally sensitive to more transient activity in primary olfactory regions, including the parahippocampal gyrus and amygdala, occurring approximately 50 ms post-inspiration. These results provide a partial validation of the spatial profile of the olfactory cascade identified by EEG source modeling, and inform novel future directions in the investigation of human olfaction.
dc.publisherELSEVIER
dc.titleThe neural cascade of olfactory processing: A combined fMRI-EEG study
dc.typeJournal Article
dc.identifier.doi10.1016/j.resp.2014.06.008
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.facultyMelbourne Medical School
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.publication.statusAccepted manuscript
melbourne.source.titleRESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
melbourne.source.monthJun-25
melbourne.identifier.nhmrc628509
melbourne.publicationid254098
melbourne.publication.chiefinvestigatorHARRISON, A/PROF BENJAMIN JAMES Ben
melbourne.publication.chiefinvestigatoremailhabj@unimelb.edu.au
melbourne.elementsidNA
melbourne.internal.embargodate2015-12-01
melbourne.contributor.authorHarding, Ian
melbourne.contributor.authorHarrison, Ben
melbourne.contributor.authorLORENZETTI, VALENTINA
melbourne.contributor.authorPantelis, Christos
melbourne.internal.ingestnoteAbstract bulk upload (2017-07-24)
melbourne.accessrightsOpen Access


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