Florey Department of Neuroscience and Mental Health - Theses
Now showing items 1-10 of 103
A novel viral based strategy to modulate specific cellular inputs in the rat brain
Communication between neurons is essential for brain function and is reliant on neural circuits that work collectively and specifically during behaviour. Several approaches, including, more recently, chemo- and opto- ...
Characterising Gene-Environment Interaction Effects on Cognition: Touchscreen Assessment of a Metabotropic Glutamate Receptor 5 Knockout Mouse Model of Cognitive Impairment Subject to Environmental Enrichment
Cognitive abilities are critical for human functioning and flourishing yet unfortunately dysfunction of cognition is a common symptom in developmental, psychiatric and neurodegenerative disorders. Observational studies in ...
The Role of the Piriform Cortex in Absence Epilepsy
The piriform cortex is critically involved in our sense of smell and engages with the olfactory network via specific neural oscillations. It is also considered to be common node of the focal epilepsy network however it is ...
Exploring the interaction between iron and tau in neurodegeneration
There is an emerging link between the accumulation of iron in the brain and abnormal tau pathology in a number of neurodegenerative disorders, such as Alzheimer’s disease (AD). In brains of AD clinical cases, high levels ...
Investigating Brain Repair and Development Using Stem Cells
The directed differentiation of human pluripotent stem cells into neuronal subtypes has generated immense enthusiasm that they could be used therapeutically or to study development in vitro. Two areas of particular interest ...
Role of relaxin-3/RXFP3 forebrain networks in descending control of pain in the mouse
Pain is a complex biological phenomenon that is beneficial and necessary for our survival, warning of changes and hazards in the environment that compromise optimal function; and it is a highly regulated biological process. ...
The nature of memory decline and learning dysfunction in preclinical Alzheimer’s disease
Background: In cognitively normal (CN) older adults, abnormal levels of amyloid-beta indicates that the pathophysiological process of Alzheimer’s disease (AD) has begun, although it may be up to 20 years before these ...
Advanced technologies for neural transplantation: new approaches for neural repair and modelling diseases
Many neurological diseases affecting the central nervous system are still incurable because of the scarce and incomplete knowledge of disease mechanisms and the lack of effective treatments. Despite the effort, these ...
The role of copper in neurodegenerative ubiquitinopathy
Ubiquitin (Ub) is one of the most stable and soluble intracellular proteins. Intriguingly, the accumulation of intracellular Ub is associated to protein aggregates that are characteristic features of neurodegenerative ...
Comprehensive touchscreen characterisation of the APP/PS1 mouse model of Alzheimer’s disease
Alzheimer’s disease is the most common form of dementia, and represents one of the biggest health challenges of our time. As such, it has been the subject of intense research for the past 20 years, but, as of yet, no ...