Florey Department of Neuroscience and Mental Health - Theses
Now showing items 1-10 of 85
Understanding the role of ATP13A2 in endo-lysosomal pathways
Parkinson’s disease (PD) is a common neurodegenerative disease affecting 1 to 2% people aged over 65. Cytoplasmic inclusions are pathognomonic of PD and point to dysregulation of protein clearance as a central part of the ...
Tryptophan hydroxylase-2 immunoreactivity changes in the dorsal raphe nucleus after chronic methamphetamine or corticosterone in BDNF-deficient mice models: Implications for schizophrenia
Schizophrenia is a major mental illness caused by genetic and environmental factors. In addition to dopaminergic dysfunction, evidence has associated 5-hydroxytryptamine (serotonin) with schizophrenia. The serotonergic ...
Biochemical mechanisms of biomineralization and elemental incorporation in otoliths: implications for fish and fisheries research
All vertebrates have small bioinorganic “earstones” in their inner ear labyrinth that are essential for hearing and balance. While otoliths play a vital anatomical role in fish, their true value to science is as biochronometers, ...
The effects of chronic methamphetamine exposure during adolescence on brain and behaviour
Methamphetamine is a highly addictive psychostimulant that is used world-wide. The age of initial methamphetamine use typically occurs during adolescence, which is a particularly vulnerable period to the development of ...
Metal regulation of extra-neuronal tau
Metal dyshomeostasis is an important neurodegenerative event that can affect the structure and function of proteins, such as tau. Tau binds metals including copper, iron and zinc, and may undergo conformational changes ...
Potassium channel gene mutations in epileptic encephalopathy
The worldwide prevalence of epilepsy is between 2-3 % with many unmet clinical and health policy needs, especially in developing countries. Current estimates suggest that as many as 70 % of all epilepsy syndromes have a ...
The role of neuroligin 3 in cognitive function
Neuroligins (NLGNs) are members of trans-synaptic protein complexes that mediate synaptic transmission and plasticity, both of which are critical for information processing and cognition. Genetic risk factors for a range ...
Undetected preclinical neurodegenerative disease in models of normal cognitive aging
With population aging, understanding cognitive changes that occur in late life is vital to support these increasing numbers of older adults to maintain their wellbeing and independence. Furthermore, accurate estimates of ...
Tau and beta-amyloid deposition, structural integrity, and cognitive function following traumatic brain injury in Australian war veterans
Background: Traumatic brain injury (TBI), has been diagnosed in over 355,000 US military service personnel since 2000. Epidemiological research indicates that veterans with TBI are two-to-four times more likely to develop ...
Investigating the therapeutic efficacy of cellular therapy for neonatal ischemic injury
Improvements in medical science have drastically increased survival for infants suffering from neonatal arterial ischemic stroke (NAIS). However, the failure to reverse the associated injuries has resulted in increased ...