Ubiquitin (Ub) is one of the most stable and soluble intracellular proteins. Intriguingly, the accumulation of intracellular Ub is associated to protein aggregates that are characteristic features of neurodegenerative ...

Alzheimer’s disease is the most common form of dementia, and represents one of the biggest health challenges of our time. As such, it has been the subject of intense research for the past 20 years, but, as of yet, no ...

Parkinson’s disease is a neurodegenerative disorder that causes motor, cognitive and neuropsychiatric deficits in patients. Current therapies do not stop ongoing neurodegeneration, and investigating biochemical features ...

Alzheimer’s disease is increasingly conceptualised as a disease of network dysfunction, which is likely underpinned by substantial white matter degeneration. Indeed, white matter is known to exhibit disruption in Alzheimer’s ...

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). The immune system plays a significant role in the pathophysiology of the disease and research into the mechanisms that may ...

Multiple System Atrophy (MSA) is an atypical parkinsonian disorder characterised by progressive neurodegeneration in substantia nigra, striatum, cerebellum, pons, inferior olives and spinal cord. The presence of protein ...

My thesis comprises of two projects, the first which investigates catechol-O-methyltransferase (COMT) protein levels by genotype (chapter 1 and 2), and the second which investigates excitatory amino acid transporter (EAAT)1 ...

Stroke is the third most common cause of death in most Western countries and the major cause of disability. The distinction between stroke subtypes and knowledge of the time of stroke onset is critical in clinical practice. ...

Schizophrenia is increasingly considered a syndrome of biologically distinct disorders. Notably, post-mortem study delineated a subgroup of subjects with decreased cortical muscarinic M1 receptors, termed muscarinic receptor ...

Proteostasis (protein homeostasis) is essential for keeping the proteome functional. This process controls protein synthesis, folding and degradation and involves hundreds of genes, including those encoding chaperones, to ...