Alzheimer’s disease is increasingly conceptualised as a disease of network dysfunction, which is likely underpinned by substantial white matter degeneration. Indeed, white matter is known to exhibit disruption in Alzheimer’s ...

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). The immune system plays a significant role in the pathophysiology of the disease and research into the mechanisms that may ...

Multiple System Atrophy (MSA) is an atypical parkinsonian disorder characterised by progressive neurodegeneration in substantia nigra, striatum, cerebellum, pons, inferior olives and spinal cord. The presence of protein ...

My thesis comprises of two projects, the first which investigates catechol-O-methyltransferase (COMT) protein levels by genotype (chapter 1 and 2), and the second which investigates excitatory amino acid transporter (EAAT)1 ...

Stroke is the third most common cause of death in most Western countries and the major cause of disability. The distinction between stroke subtypes and knowledge of the time of stroke onset is critical in clinical practice. ...

Schizophrenia is increasingly considered a syndrome of biologically distinct disorders. Notably, post-mortem study delineated a subgroup of subjects with decreased cortical muscarinic M1 receptors, termed muscarinic receptor ...

Proteostasis (protein homeostasis) is essential for keeping the proteome functional. This process controls protein synthesis, folding and degradation and involves hundreds of genes, including those encoding chaperones, to ...

Parkinson’s disease (PD) is a common neurodegenerative disease affecting 1 to 2% people aged over 65. Cytoplasmic inclusions are pathognomonic of PD and point to dysregulation of protein clearance as a central part of the ...

Schizophrenia is a major mental illness caused by genetic and environmental factors. In addition to dopaminergic dysfunction, evidence has associated 5-hydroxytryptamine (serotonin) with schizophrenia. The serotonergic ...

All vertebrates have small bioinorganic “earstones” in their inner ear labyrinth that are essential for hearing and balance. While otoliths play a vital anatomical role in fish, their true value to science is as biochronometers, ...