Florey Department of Neuroscience and Mental Health - Theses
Now showing items 1-10 of 88
Specific biomarkers for acute stroke: comparison between human and animal models and development of a new way to improve acute stroke conditions
Stroke is the third most common cause of death in most Western countries and the major cause of disability. The distinction between stroke subtypes and knowledge of the time of stroke onset is critical in clinical practice. ...
The hippocampal muscarinic M1 receptor and SLC39A12 gene in the pathophysiology of schizophrenia
Schizophrenia is increasingly considered a syndrome of biologically distinct disorders. Notably, post-mortem study delineated a subgroup of subjects with decreased cortical muscarinic M1 receptors, termed muscarinic receptor ...
Spatial and temporal surveillance of the mechanisms controlling proteome foldedness via a FRET-based biosensor
Proteostasis (protein homeostasis) is essential for keeping the proteome functional. This process controls protein synthesis, folding and degradation and involves hundreds of genes, including those encoding chaperones, to ...
Understanding the role of ATP13A2 in endo-lysosomal pathways
Parkinson’s disease (PD) is a common neurodegenerative disease affecting 1 to 2% people aged over 65. Cytoplasmic inclusions are pathognomonic of PD and point to dysregulation of protein clearance as a central part of the ...
Tryptophan hydroxylase-2 immunoreactivity changes in the dorsal raphe nucleus after chronic methamphetamine or corticosterone in BDNF-deficient mice models: Implications for schizophrenia
Schizophrenia is a major mental illness caused by genetic and environmental factors. In addition to dopaminergic dysfunction, evidence has associated 5-hydroxytryptamine (serotonin) with schizophrenia. The serotonergic ...
Biochemical mechanisms of biomineralization and elemental incorporation in otoliths: implications for fish and fisheries research
All vertebrates have small bioinorganic “earstones” in their inner ear labyrinth that are essential for hearing and balance. While otoliths play a vital anatomical role in fish, their true value to science is as biochronometers, ...
The effects of chronic methamphetamine exposure during adolescence on brain and behaviour
Methamphetamine is a highly addictive psychostimulant that is used world-wide. The age of initial methamphetamine use typically occurs during adolescence, which is a particularly vulnerable period to the development of ...
Metal regulation of extra-neuronal tau
Metal dyshomeostasis is an important neurodegenerative event that can affect the structure and function of proteins, such as tau. Tau binds metals including copper, iron and zinc, and may undergo conformational changes ...
Potassium channel gene mutations in epileptic encephalopathy
The worldwide prevalence of epilepsy is between 2-3 % with many unmet clinical and health policy needs, especially in developing countries. Current estimates suggest that as many as 70 % of all epilepsy syndromes have a ...
The role of neuroligin 3 in cognitive function
Neuroligins (NLGNs) are members of trans-synaptic protein complexes that mediate synaptic transmission and plasticity, both of which are critical for information processing and cognition. Genetic risk factors for a range ...