Florey Department of Neuroscience and Mental Health - Theses
Now showing items 1-10 of 100
Exploring the interaction between iron and tau in neurodegeneration
There is an emerging link between the accumulation of iron in the brain and abnormal tau pathology in a number of neurodegenerative disorders, such as Alzheimer’s disease (AD). In brains of AD clinical cases, high levels ...
Investigating Brain Repair and Development Using Stem Cells
The directed differentiation of human pluripotent stem cells into neuronal subtypes has generated immense enthusiasm that they could be used therapeutically or to study development in vitro. Two areas of particular interest ...
Role of relaxin-3/RXFP3 forebrain networks in descending control of pain in the mouse
Pain is a complex biological phenomenon that is beneficial and necessary for our survival, warning of changes and hazards in the environment that compromise optimal function; and it is a highly regulated biological process. ...
The nature of memory decline and learning dysfunction in preclinical Alzheimer’s disease
Background: In cognitively normal (CN) older adults, abnormal levels of amyloid-beta indicates that the pathophysiological process of Alzheimer’s disease (AD) has begun, although it may be up to 20 years before these ...
Advanced technologies for neural transplantation: new approaches for neural repair and modelling diseases
Many neurological diseases affecting the central nervous system are still incurable because of the scarce and incomplete knowledge of disease mechanisms and the lack of effective treatments. Despite the effort, these ...
The role of copper in neurodegenerative ubiquitinopathy
Ubiquitin (Ub) is one of the most stable and soluble intracellular proteins. Intriguingly, the accumulation of intracellular Ub is associated to protein aggregates that are characteristic features of neurodegenerative ...
Comprehensive touchscreen characterisation of the APP/PS1 mouse model of Alzheimer’s disease
Alzheimer’s disease is the most common form of dementia, and represents one of the biggest health challenges of our time. As such, it has been the subject of intense research for the past 20 years, but, as of yet, no ...
An investigation into the toxic mechanism of alpha-synuclein: implications for Parkinson’s disease therapeutics
Parkinson’s disease is a neurodegenerative disorder that causes motor, cognitive and neuropsychiatric deficits in patients. Current therapies do not stop ongoing neurodegeneration, and investigating biochemical features ...
Probing white matter pathology in Alzheimer's disease using advanced diffusion MRI
Alzheimer’s disease is increasingly conceptualised as a disease of network dysfunction, which is likely underpinned by substantial white matter degeneration. Indeed, white matter is known to exhibit disruption in Alzheimer’s ...
The effect of genetic susceptibility and immunosuppressant treatment on mononuclear cell phenotype in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). The immune system plays a significant role in the pathophysiology of the disease and research into the mechanisms that may ...