Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disorder, which is characterised by an increasing impairment in memory and cognitive skills that significantly hinders a person’s daily functioning. ...

Venous thromboembolism (VTE) is a major cause of mortality and morbidity. The management of VTE, however, remains heterogeneous, particularly with “minor” VTEs (defined as provoked VTE and distal deep vein thrombosis (DVT)). ...

Phagocytosis is one of the most important functions of innate immunity. Non-opsonised phagocytosis by monocytes and macrophages is a phagocytic process without involvements of antibodies and important in removing pathogens ...

Few animal models of stroke have created haematomas that mimic the processes seen in humans. We developed a new model of intracerebral haemorrhage (ICH) in rats by inducing acute-on-chronic hypertension that more closely ...

In recent years, striking new evidence has demonstrated non-genetic inheritance of acquired traits associated with parental environmental exposures. Many of these effects involve the paternal transmission of epigenetic ...

Schizophrenia is a severe neuropsychiatric disorder characterised by positive symptoms such as delusions and hallucinations, negative symptoms such as amotivation and asociality and cognitive symptoms such as working memory ...

Relaxin-3 is an evolutionary conserved neuropeptide highly expressed by γ-aminobutyric acid (GABA) projection neurons in hindbrain regions including the nucleus incertus, which acts via its cognate Gi/o-protein-coupled ...

Drinking in response to dehydration is a tightly regulated behaviour that accurately corrects the fluid deficit present within the body. The critical importance of this behaviour is underlined by its conservation across ...

Neuronal cultures grown on multielectrode arrays (MEAs) capture the electrical signals from neuronal networks of thousands of neurons in parallel, thus providing insight into interconnections and network activity. Though ...

Alcohol use disorders are chronic relapsing conditions that represent one of the leading causes of preventable death. The enduring propensity to relapse is one of the fundamental features of alcohol use disorders and ...