Florey Department of Neuroscience and Mental Health - Theses
Now showing items 1-10 of 95
The role of copper in neurodegenerative ubiquitinopathy
Ubiquitin (Ub) is one of the most stable and soluble intracellular proteins. Intriguingly, the accumulation of intracellular Ub is associated to protein aggregates that are characteristic features of neurodegenerative ...
Comprehensive touchscreen characterisation of the APP/PS1 mouse model of Alzheimer’s disease
Alzheimer’s disease is the most common form of dementia, and represents one of the biggest health challenges of our time. As such, it has been the subject of intense research for the past 20 years, but, as of yet, no ...
An investigation into the toxic mechanism of alpha-synuclein: implications for Parkinson’s disease therapeutics
Parkinson’s disease is a neurodegenerative disorder that causes motor, cognitive and neuropsychiatric deficits in patients. Current therapies do not stop ongoing neurodegeneration, and investigating biochemical features ...
Probing white matter pathology in Alzheimer's disease using advanced diffusion MRI
Alzheimer’s disease is increasingly conceptualised as a disease of network dysfunction, which is likely underpinned by substantial white matter degeneration. Indeed, white matter is known to exhibit disruption in Alzheimer’s ...
The effect of genetic susceptibility and immunosuppressant treatment on mononuclear cell phenotype in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). The immune system plays a significant role in the pathophysiology of the disease and research into the mechanisms that may ...
α-synuclein, iron and Multiple System Atrophy
Multiple System Atrophy (MSA) is an atypical parkinsonian disorder characterised by progressive neurodegeneration in substantia nigra, striatum, cerebellum, pons, inferior olives and spinal cord. The presence of protein ...
Catechol metabolism and glutamate uptake in the prefrontal cortex of subjects with schizophrenia: implications for cognitive function
My thesis comprises of two projects, the first which investigates catechol-O-methyltransferase (COMT) protein levels by genotype (chapter 1 and 2), and the second which investigates excitatory amino acid transporter (EAAT)1 ...
Specific biomarkers for acute stroke: comparison between human and animal models and development of a new way to improve acute stroke conditions
Stroke is the third most common cause of death in most Western countries and the major cause of disability. The distinction between stroke subtypes and knowledge of the time of stroke onset is critical in clinical practice. ...
The hippocampal muscarinic M1 receptor and SLC39A12 gene in the pathophysiology of schizophrenia
Schizophrenia is increasingly considered a syndrome of biologically distinct disorders. Notably, post-mortem study delineated a subgroup of subjects with decreased cortical muscarinic M1 receptors, termed muscarinic receptor ...
Spatial and temporal surveillance of the mechanisms controlling proteome foldedness via a FRET-based biosensor
Proteostasis (protein homeostasis) is essential for keeping the proteome functional. This process controls protein synthesis, folding and degradation and involves hundreds of genes, including those encoding chaperones, to ...