With population aging, understanding cognitive changes that occur in late life is vital to support these increasing numbers of older adults to maintain their wellbeing and independence. Furthermore, accurate estimates of ...

Background: Traumatic brain injury (TBI), has been diagnosed in over 355,000 US military service personnel since 2000. Epidemiological research indicates that veterans with TBI are two-to-four times more likely to develop ...

Improvements in medical science have drastically increased survival for infants suffering from neonatal arterial ischemic stroke (NAIS). However, the failure to reverse the associated injuries has resulted in increased ...

Inhalant abuse is the intentional inhalation of products containing toluene (e.g. glue or petrol) in order to induce an altered mental state. The primary populations who misuse inhalants are adolescents, particularly those ...

Cardiorespiratory fitness (CRF) levels are low in stroke survivors. Although there is strong evidence that physical fitness training improves CRF in stroke survivors, there is a lack of knowledge about the safety and ...

Alzheimer's disease is a neurodegenerative condition characterized by progressive cognitive decline and cerebral deposition of fibrillar plaques comprised of the β–amyloid (Aβ) peptide. According to the current state of ...

Many candidate neuroprotective drugs work in animal models of stroke but don’t work in the human condition. In this thesis, I have developed culture systems that will allow human stem cell derived neurons to be used to ...

Very preterm (VP) infants who are born at less than 32 weeks’ completed gestation are at an increased risk for poorer long-term cognitive, motor and behavioural outcomes, compared with their term-born peers. The basal ...

Relaxin-3 is a highly conserved neuropeptide that activates the Relaxin Family Peptide Receptor 3 (RXFP3). The relaxin-3/RXFP3 neuropeptide system is involved in the modulation of stress, appetite, mood, cognition, memory ...

In acute ischemic stroke the ischemic penumbra is the abnormal cerebral tissue and its salvage could improve clinical outcome. I have published four papers demonstrating different penumbral patterns which change with time ...