Florey Department of Neuroscience and Mental Health - Theses
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Undetected preclinical neurodegenerative disease in models of normal cognitive aging
With population aging, understanding cognitive changes that occur in late life is vital to support these increasing numbers of older adults to maintain their wellbeing and independence. Furthermore, accurate estimates of ...
Tau and beta-amyloid deposition, structural integrity, and cognitive function following traumatic brain injury in Australian war veterans
Background: Traumatic brain injury (TBI), has been diagnosed in over 355,000 US military service personnel since 2000. Epidemiological research indicates that veterans with TBI are two-to-four times more likely to develop ...
Investigating the therapeutic efficacy of cellular therapy for neonatal ischemic injury
Improvements in medical science have drastically increased survival for infants suffering from neonatal arterial ischemic stroke (NAIS). However, the failure to reverse the associated injuries has resulted in increased ...
The growth and energy balance consequences of adolescent inhalant abuse
Inhalant abuse is the intentional inhalation of products containing toluene (e.g. glue or petrol) in order to induce an altered mental state. The primary populations who misuse inhalants are adolescents, particularly those ...
Cardiorespiratory fitness training early after stroke
Cardiorespiratory fitness (CRF) levels are low in stroke survivors. Although there is strong evidence that physical fitness training improves CRF in stroke survivors, there is a lack of knowledge about the safety and ...
N-truncation of Aβ peptides and Cu(II) binding: affinity, structures, reactivity
Alzheimer's disease is a neurodegenerative condition characterized by progressive cognitive decline and cerebral deposition of fibrillar plaques comprised of the β–amyloid (Aβ) peptide. According to the current state of ...
Human in vitro models of ischaemic stroke: new strategies for neuroprotection
Many candidate neuroprotective drugs work in animal models of stroke but don’t work in the human condition. In this thesis, I have developed culture systems that will allow human stem cell derived neurons to be used to ...
Understanding basal ganglia and thalamic development in very preterm infants
Very preterm (VP) infants who are born at less than 32 weeks’ completed gestation are at an increased risk for poorer long-term cognitive, motor and behavioural outcomes, compared with their term-born peers. The basal ...
Understanding the interactions of relaxin-3 with its receptor RXFP3
Relaxin-3 is a highly conserved neuropeptide that activates the Relaxin Family Peptide Receptor 3 (RXFP3). The relaxin-3/RXFP3 neuropeptide system is involved in the modulation of stress, appetite, mood, cognition, memory ...
The ischemic penumbra - its topography, duration and clinical effect
In acute ischemic stroke the ischemic penumbra is the abnormal cerebral tissue and its salvage could improve clinical outcome. I have published four papers demonstrating different penumbral patterns which change with time ...