Florey Department of Neuroscience and Mental Health - Theses
Now showing items 1-10 of 74
Cardiorespiratory fitness training early after stroke
Cardiorespiratory fitness (CRF) levels are low in stroke survivors. Although there is strong evidence that physical fitness training improves CRF in stroke survivors, there is a lack of knowledge about the safety and ...
N-truncation of Aβ peptides and Cu(II) binding: affinity, structures, reactivity
Alzheimer's disease is a neurodegenerative condition characterized by progressive cognitive decline and cerebral deposition of fibrillar plaques comprised of the β–amyloid (Aβ) peptide. According to the current state of ...
Human in vitro models of ischaemic stroke: new strategies for neuroprotection
Many candidate neuroprotective drugs work in animal models of stroke but don’t work in the human condition. In this thesis, I have developed culture systems that will allow human stem cell derived neurons to be used to ...
Understanding basal ganglia and thalamic development in very preterm infants
Very preterm (VP) infants who are born at less than 32 weeks’ completed gestation are at an increased risk for poorer long-term cognitive, motor and behavioural outcomes, compared with their term-born peers. The basal ...
Understanding the interactions of relaxin-3 with its receptor RXFP3
Relaxin-3 is a highly conserved neuropeptide that activates the Relaxin Family Peptide Receptor 3 (RXFP3). The relaxin-3/RXFP3 neuropeptide system is involved in the modulation of stress, appetite, mood, cognition, memory ...
The ischemic penumbra - its topography, duration and clinical effect
In acute ischemic stroke the ischemic penumbra is the abnormal cerebral tissue and its salvage could improve clinical outcome. I have published four papers demonstrating different penumbral patterns which change with time ...
Applying matrix assisted laser desorption-ionization mass spectrometry to identify and quantify isoforms of amyloid beta in human brain
Amyloid beta (Aβ) plays a central pathogenic role in Alzheimer's Disease (AD), however its great heterogeneity remains largely unexplored as most research focuses on only two specific species: Aβ1-40 and Aβ1-42. More than ...
The mechanism of action of clioquinol for the treatment of Alzheimer's disease
Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disorder, which is characterised by an increasing impairment in memory and cognitive skills that significantly hinders a person’s daily functioning. ...
Evaluation of the management of venous thromboembolism and application of novel global coagulation assays
Venous thromboembolism (VTE) is a major cause of mortality and morbidity. The management of VTE, however, remains heterogeneous, particularly with “minor” VTEs (defined as provoked VTE and distal deep vein thrombosis (DVT)). ...
P2X7 mediated innate phagocytosis and its role in human diseases
Phagocytosis is one of the most important functions of innate immunity. Non-opsonised phagocytosis by monocytes and macrophages is a phagocytic process without involvements of antibodies and important in removing pathogens ...