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dc.contributor.authorLim, YYen_US
dc.contributor.authorVillemagne, VLen_US
dc.contributor.authorLaws, SMen_US
dc.contributor.authorAmes, Den_US
dc.contributor.authorPietrzak, RHen_US
dc.contributor.authorEllis, KAen_US
dc.contributor.authorHarrington, Ken_US
dc.contributor.authorBourgeat, Pen_US
dc.contributor.authorBush, AIen_US
dc.contributor.authorMartins, RNen_US
dc.contributor.authorMasters, CLen_US
dc.contributor.authorRowe, CCen_US
dc.contributor.authorMaruff, Pen_US
dc.date.available2015-03-16T03:33:18Z
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.available2013-12-10en_US
dc.date.issued2014-01-27en_US
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330507300072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1cen_US
dc.identifierARTN e86498en_US
dc.identifier.citationLim, YY; Villemagne, VL; Laws, SM; Ames, D; Pietrzak, RH; Ellis, KA; Harrington, K; Bourgeat, P; Bush, AI; Martins, RN; Masters, CL; Rowe, CC; Maruff, P, Effect of BDNF Val66Met on Memory Decline and Hippocampal Atrophy in Prodromal Alzheimer's Disease: A Preliminary Study, PLOS ONE, 2014, 9 (1)en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/11343/51264
dc.description.abstractOBJECTIVE: Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ. METHODS: Thirty-four adults with aMCI were recruited from the Australian, Imaging, Biomarkers and Lifestyle (AIBL) Study. Participants underwent PiB-PET and structural MRI neuroimaging, neuropsychological assessments and BDNF genotyping at baseline, 18 month, and 36 month assessments. RESULTS: In individuals with aMCI and high Aβ, Met carriers showed significant and large decline in episodic memory (d = 0.90, p = .020) and hippocampal volume (d = 0.98, p = .035). BDNF Val66Met was unrelated to the rate of Aβ accumulation (d = -0.35, p = .401). CONCLUSIONS: Although preliminary due to the small sample size, results of this study suggest that high Aβ levels and Met carriage may be useful prognostic markers of accelerated decline in episodic memory, and reductions in hippocampal volume in individuals in the prodromal or MCI stage of AD.
dc.languageEnglishen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.titleEffect of BDNF Val66Met on Memory Decline and Hippocampal Atrophy in Prodromal Alzheimer's Disease: A Preliminary Studyen_US
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0086498en_US
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentPathology
melbourne.affiliation.departmentPsychiatry
melbourne.source.titlePLOS ONEen_US
melbourne.source.volume9en_US
melbourne.source.issue1en_US
melbourne.identifier.nhmrc1037234
melbourne.elementsid690865
pubs.publication-statusPublisheden_US
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903533
melbourne.contributor.authorAmes, David
melbourne.contributor.authorBush, Ashley
melbourne.contributor.authorRowe, Christopher
melbourne.contributor.authorVillemagne, Victor
melbourne.contributor.authorEllis, Kathryn
melbourne.contributor.authorMaruff, Paul
melbourne.contributor.authorMasters, Colin
melbourne.contributor.authorHarrington, Karra
melbourne.contributor.authorLim, Yen Ying
melbourne.contributor.orcidEllis, Kathryn A [0000-0001-9097-9037]
melbourne.contributor.orcidHarrington, Karra [0000-0001-9230-2978]
melbourne.contributor.orcidBush, Ashley I [0000-0001-8259-9069]
melbourne.contributor.orcidMasters, Colin L [0000-0003-3072-7940]
melbourne.contributor.orcidMaruff, Paul [0000-0002-6947-9537]
melbourne.accessrightsOpen Access


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