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dc.contributor.authorPASK, A
dc.contributor.authorPhillips, TR
dc.contributor.authorWright, DK
dc.contributor.authorGradie, PE
dc.contributor.authorJohnston, LA
dc.date.available2015-05-21T02:29:09Z
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.available2015-03-02
dc.date.issued2015
dc.identifierpii: 000431010
dc.identifier.citationPASK, A., Phillips, T. R., Wright, D. K., Gradie, P. E. & Johnston, L. A. (2015). A Comprehensive Atlas of the Adult Mouse Penis. Sexual Development, 9 (2), pp.162-172. https://doi.org/10.1159/000431010.
dc.identifier.issn1661-5425
dc.identifier.urihttp://hdl.handle.net/11343/54723
dc.description.abstractMice are routinely used to study the development of the external genitalia and, in particular, the process of male urethral closure. This is because misplacement of the male penile urethra, or hypospadias, is amongst the most common birth defects reported in humans. While mice present a tractable model to study penile development, several structures differ between mice and humans and there is a lack of consensus in the literature on their annotation and developmental origins. Defining the ontology of the mouse prepuce is especially important for the relevance and interpretation of mouse models of hypospadias to human conditions. We have developed a detailed annotation of the adult mouse penis that addresses these differences and enables an accurate comparison of murine and human hypospadias phenotypes. Through magnetic resonance imaging data, gross morphology, and section histology, we define the origin of the mouse external and internal prepuces, their relationship to the single human foreskin, as well as provide a comprehensive view of the various structures of the mouse penis and their associated muscle attachments within the body. These data are combined to annotate structures in a novel 3D adult penis atlas that can be downloaded, viewed at any angle, and manipulated to examine the relationship of various structures.
dc.languageEnglish
dc.publisherKarger
dc.titleA Comprehensive Atlas of the Adult Mouse Penis
dc.typeJournal Article
dc.identifier.doi10.1159/000431010
melbourne.affiliation.departmentZoology
melbourne.source.titleSexual Development
melbourne.source.volume9
melbourne.source.issue2
melbourne.source.pages162-172
melbourne.elementsid977231
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012965
melbourne.contributor.authorPask, Andrew
melbourne.contributor.authorJohnston, Leigh
melbourne.contributor.authorWright, David
melbourne.contributor.authorPhillips, Tiffany
melbourne.contributor.authorGradie, Paul
dc.identifier.eissn1661-5433
melbourne.identifier.fundernameidNATIONAL INSTITUTE OF HEALTH, 5R01DK096263
melbourne.accessrightsOpen Access


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