School of Biomedical Sciences - Research Publications
Now showing items 1-10 of 91
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
(PUBLIC LIBRARY SCIENCE, 2015-04-01)
Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is ...
5-HT1A, SST1, and SST2 receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum
(AMER PHYSIOLOGICAL SOC, 2010-03-01)
Vasoactive intestinal peptide (VIP) immunoreactive neurons are important secretomotor neurons in the submucous plexus. They are the only submucosal neurons to receive inhibitory inputs and exhibit both noradrenergic and ...
Biological metals and metal-targeting compounds in major neurodegenerative diseases
(ROYAL SOC CHEMISTRY, 2014-01-01)
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral ...
Human to mosquito transmiss on of dengue viruses
(FRONTIERS RESEARCH FOUNDATION, 2014-06-17)
The successful transmission of dengue virus from a human host to a mosquito vector requires a complex set of factors to align. It is becoming increasingly important to improve our understanding of the parameters that shape ...
Generation of adaptive immune responses following influenza virus challenge is not compromised by pre-treatment with the TLR-2 agonist Pam(2)Cys
(FRONTIERS MEDIA SA, 2015-06-05)
Immunostimulatory agents provide a new category of anti-microbial agents that activate the host's innate immune system allowing control of viral and/or bacterial infections. The TLR-2 agonist PEG-Pam2Cys has been shown to ...
Monoclonal antibody therapy for the treatment of asthma and chronic obstructive pulmonary disease with eosinophilic inflammation
(PERGAMON-ELSEVIER SCIENCE LTD, 2017-01-01)
Eosinophils have been linked with asthma for more than a century, but their role has been unclear. This review discusses the roles of eosinophils in asthma and chronic obstructive pulmonary disease (COPD) and describes ...
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles
(ROCKEFELLER UNIV PRESS, 2015-08-17)
Prion-like domains (PLDs) are low complexity sequences found in RNA binding proteins associated with the neurodegenerative disorder amyotrophic lateral sclerosis. Recently, PLDs have been implicated in mediating gene ...
Coxiella burnetii: turning hostility into a home
Coxiella burnetii, the causative agent of the human disease Q fever, is a unique intracellular bacterial pathogen. Coxiella replicates to high numbers within a pathogen-derived lysosome-like vacuole, thriving within a low ...
Putting Huntingtin "Aggregation" in View with Windows into the Cellular Milieu
(BENTHAM SCIENCE PUBL LTD, 2012-11-01)
Huntington's disease arises from CAG codon-repeat expansions in the Htt gene, which leads to a Htt gene product with an expanded polyglutamine (polyQ) sequence. The length of the polyQ expansion correlates with an increased ...
Purification and characterization of relaxin from the tammar wallaby (Macropus eugenii): Bioactivity and expression in the corpus luteum
(SOC STUDY REPRODUCTION, 2002-07-01)
The objective of this study was to isolate and purify prorelaxin or mature relaxin from the tammar wallaby corpus luteum (CL), determine their structure and bioactivity, and test the hypothesis that enzymatic cleavage of ...