School of Biomedical Sciences - Research Publications
Now showing items 1-10 of 69
Five decades of genome evolution in the globally distributed, extensively antibiotic resistant Acinetobacter baumannii global clone 1
(Microbial Society, 2016-01-18)
The majority of Acinetobacter baumannii isolates that are multiply, extensively and pan-antibiotic resistant belong to two globally disseminated clones, GC1 and GC2, that were first noticed in the 1970s. Here, we investigated ...
Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy
(Hindawi Publishing Corporation, 2015)
Variants of ST8SIA1 Are Associated with Risk of Developing Multiple Sclerosis
(PUBLIC LIBRARY SCIENCE, 2008-07-09)
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system of unknown etiology with both genetic and environmental factors playing a role in susceptibility. To date, the HLA DR15/DQ6 ...
Multiple Sclerosis Susceptibility-Associated SNPs Do Not Influence Disease Severity Measures in a Cohort of Australian MS Patients
(PUBLIC LIBRARY SCIENCE, 2010-04-02)
Recent association studies in multiple sclerosis (MS) have identified and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 and chromosome 12q13-14 ...
A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis
(PUBLIC LIBRARY SCIENCE, 2010-10-26)
We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we ...
Monoclonal antibody therapy for the treatment of asthma and chronic obstructive pulmonary disease with eosinophilic inflammation
(PERGAMON-ELSEVIER SCIENCE LTD, 2017-01-01)
Eosinophils have been linked with asthma for more than a century, but their role has been unclear. This review discusses the roles of eosinophils in asthma and chronic obstructive pulmonary disease (COPD) and describes ...
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
(PUBLIC LIBRARY SCIENCE, 2015-04-01)
Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is ...
Membrane-bound tetramer and trimer A beta oligomeric species correlate with toxicity towards cultured neurons
Amyloid beta (Aβ) peptide is the major constituent of the extracellular amyloid plaques deposited in the brains of Alzheimer's disease patients and is central to the pathogenic pathway causing this disease. The identity ...
Identifying polyglutamine protein species in situ that best predict neurodegeneration
(NATURE PUBLISHING GROUP, 2011-12-01)
Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function to proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although ...
Golgi-localized STELLO proteins regulate the assembly and trafficking of cellulose synthase complexes in Arabidopsis
(NATURE PUBLISHING GROUP, 2016-06-01)
As the most abundant biopolymer on Earth, cellulose is a key structural component of the plant cell wall. Cellulose is produced at the plasma membrane by cellulose synthase (CesA) complexes (CSCs), which are assembled in ...