School of Biomedical Sciences - Theses
Now showing items 1-10 of 25
Synaptic mechanisms and function in the mouse enteric nervous system
Virtually all functions of the enteric nervous system (ENS) rely on synaptic transmission, which occurs at specialised sites referred to as synapses. Molecular mechanisms behind synaptic transmission at central synapses ...
Impact of respiratory syncytial virus infection on host mitochondrial organisation and function
Respiratory syncytial virus (RSV), a leading cause of acute lower respiratory illness in infants, immunosuppressed adults and the elderly, is responsible for more deaths each year than influenza. Despite this, there are ...
Elucidation of the roles of the lyssavirus P3 protein-microtubule interface in viral immune evasion and pathogenesis
Central to the capacity of many viruses to cause disease are their ability to subvert the host-cell’s innate antiviral immune defence, the interferon (IFN) response, through expression of IFN antagonist proteins. For ...
Pathways to HIV latency and reactivation in vitro
Human immunodeficiency virus (HIV) infection remains a major global health issue. Antiretroviral drugs improve life expectancy and significantly reduce the rate of viral transmission; however, we are far from finding a ...
Metal regulation of extra-neuronal tau
Metal dyshomeostasis is an important neurodegenerative event that can affect the structure and function of proteins, such as tau. Tau binds metals including copper, iron and zinc, and may undergo conformational changes ...
Adipose, sex steroids and atrial arrhythmia vulnerability
Background: Pericardial adipose deposition occurs in ageing and obesity, and independently contributes to the development of atrial fibrillation. The mechanisms underlying this association are not yet understood. ...
Molecular mechanisms of artemisinin action and resistance in the malaria parasite Plasmodium falciparum
Malaria is the disease caused by infection of red blood cells with the protozoan parasite, Plasmodium. In 2016 alone, 216 million people suffered from malaria, leading to 445 000 deaths. Artemisinin-based combination ...
Investigating the functional roles of microRNA-29b and microRNA-146a in prion diseases
Neurodegenerative diseases such as Alzheimer’s disease and prion disease are closely related with specific gene and protein dysfunction. Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are ...
Characterization of cyclic nucleotide-mediated signal transduction pathways in Toxoplasma gondii
T. gondii is amongst the most common human pathogens, chronically infecting more than 30% of the human population. T. gondii has a complex life cycle, often spanning multiple hosts. T. gondii parasites invade target host ...
Defining the roles of essential genes in the malaria parasite life cycle
The combination of drug resistance, lack of an effective vaccine and ongoing conflict and poverty mean that malaria remains a major global health crisis. Understanding metabolic pathways at all parasite life stages is ...