School of Biomedical Sciences - Theses
Now showing items 1-10 of 19
Molecular mechanisms of artemisinin action and resistance in the malaria parasite Plasmodium falciparum
Malaria is the disease caused by infection of red blood cells with the protozoan parasite, Plasmodium. In 2016 alone, 216 million people suffered from malaria, leading to 445 000 deaths. Artemisinin-based combination ...
Investigating the functional roles of microRNA-29b and microRNA-146a in prion diseases
Neurodegenerative diseases such as Alzheimer’s disease and prion disease are closely related with specific gene and protein dysfunction. Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are ...
Characterization of cyclic nucleotide-mediated signal transduction pathways in Toxoplasma gondii
T. gondii is amongst the most common human pathogens, chronically infecting more than 30% of the human population. T. gondii has a complex life cycle, often spanning multiple hosts. T. gondii parasites invade target host ...
Defining the roles of essential genes in the malaria parasite life cycle
The combination of drug resistance, lack of an effective vaccine and ongoing conflict and poverty mean that malaria remains a major global health crisis. Understanding metabolic pathways at all parasite life stages is ...
Pathology of glycogen excess in diabetic cardiomyopathy
Background: Diabetic cardiomyopathy is a distinct cardiac pathology and the underlying mechanisms are unknown. Elevated glycogen content has been observed in the diabetic human myocardium, first recorded 80 years ago, ...
Exploring adaptation in a key Australian genus Brachyscome through experimentation
This thesis focuses on species adaptation in a key Australian genus Brachyscome, using three central themes in ecological theory; plants perform better where they naturally occur (local adaptation), widespread species ...
Investigating the role of NK cells in allogeneic haematopoietic stem cell transplantation
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is used to treat a range of haematological malignancies. However, the use of allo-HSCT is limited due to significant toxicity related to conditioning intensity, ...
Defining and developing novel host targeted therapies to eliminate Mycobacterium tuberculosis infections
Tuberculosis, caused by Mycobacterium tuberculosis (M.tb), is a massive global health problem with one third of the world’s population infected. Aproximately two billion people have been killed by tuberculosis over the ...
Understanding the factors that drive the emergence of dominant gene constellations during influenza A virus reassortment
The segmented nature of the influenza genome allows the virus to undergo reassortment (gene swapping) upon co-infection of a single cell. This process is a major contributing factor to the emergence of novel pandemic strains ...
Exploring the role of early life respiratory infection in asthma
The underlying cause of asthma is yet to be determined. Asthma is presently the most common chronic disease affecting children, and it is becoming clear that disease originates in early life and as a result of complex ...