Melbourne School of Health Sciences Collected Works - Theses
Now showing items 1-10 of 13
Characterising the ocular phenotype in a murine model of Alzheimer’s disease
This thesis shows that amyloid beta found in the brain is also present in the retina of a murine model of Alzheimer’s disease. By applying non-invasive retinal techniques, we show that neuronal structural and functional ...
Investigating the functional roles of microRNA-29b and microRNA-146a in prion diseases
Neurodegenerative diseases such as Alzheimer’s disease and prion disease are closely related with specific gene and protein dysfunction. Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are ...
Modelling residential aged care in Australia: entry and exit
Ageing of the Australian population affects the residential aged care system, yet the structure and dynamics of the system remain uncertain. A comprehensive model of residential care based on the individual perspective of ...
Perceptual suppression mechanisms in healthy ageing
Healthy ageing alters contextual spatial interactions such as centre surround contrast suppression and spatial suppression of motion discrimination. However, the exact neural mechanisms that underlie age related changes ...
The role of Dlk1 in haematopoiesis, leukaemia and angiogenesis
Delta-Like Homologue 1 (DLK1), also known as Preadipocyte Factor 1 (PREF-1), is a non-canonical EGF-like NOTCH ligand. It is maternally imprinted at the Dlk1-Dio3 imprinted locus, and has been shown to regulate embryonic ...
Swallowing difficulties in Friedreich ataxia
Swallowing is an important biological function reliant on the coordinated interaction between motor and sensory mechanisms. Swallowing dysfunction (dysphagia) is a common sequela of neurodegenerative disease and is ...
Toward relationship-centred care: patient-physiotherapist interaction in private practice
Interacting with patients is integral to the practice of physiotherapy. Notably, however, empirically derived knowledge about how physiotherapists interact with their patients is limited, particularly in the private practice ...
“I knew it was wrong but I couldn’t stop it”: young people talk about the prevention of sexually abusive behaviour
Child sexual abuse perpetrated by adults in family and institutional contexts is a well-known phenomenon. Child sexual abuse carried out by other children and young people, however, is a comparatively underexplored social ...
Active video game technologies for balance rehabilitation after stroke
Standing balance deficits are frequent and disabling following stroke; however, optimal assessment and treatment for balance problems remains unclear. The past decade has seen the increasing emergence and clinical uptake ...
Biomechanical and neuromuscular impairments in individuals with gluteal tendinopathy
Gluteal Tendinopathy (GT) is a typically chronic, recalcitrant cause of lateral hip pain most commonly seen in women aged 40 to 70 years. The condition involves pathology of the gluteus minimus and/or gluteus medius tendons ...