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dc.contributor.authorBahlo, M
dc.contributor.authorBooth, DR
dc.contributor.authorBroadley, SA
dc.contributor.authorBrown, MA
dc.contributor.authorFoote, SJ
dc.contributor.authorGriffiths, LR
dc.contributor.authorKilpatrick, TJ
dc.contributor.authorLechner-Scott, J
dc.contributor.authorMoscato, P
dc.contributor.authorPerreau, VM
dc.contributor.authorRubio, JP
dc.contributor.authorScott, RJ
dc.contributor.authorStankovich, J
dc.contributor.authorStewart, GJ
dc.contributor.authorTaylor, BV
dc.contributor.authorWiley, J
dc.contributor.authorClarke, G
dc.contributor.authorCox, MB
dc.contributor.authorCsurhes, PA
dc.contributor.authorDanoy, P
dc.contributor.authorDrysdale, K
dc.contributor.authorField, J
dc.contributor.authorFoote, SJ
dc.contributor.authorGreer, JM
dc.contributor.authorGuru, P
dc.contributor.authorHadler, J
dc.contributor.authorMcMorran, BJ
dc.contributor.authorJensen, CJ
dc.contributor.authorJohnson, LJ
dc.contributor.authorMcCallum, R
dc.contributor.authorMerriman, M
dc.contributor.authorMerriman, T
dc.contributor.authorPryce, K
dc.contributor.authorTajouri, L
dc.contributor.authorWilkins, EJ
dc.contributor.authorBrowning, BL
dc.contributor.authorBrowning, SR
dc.contributor.authorPerera, D
dc.contributor.authorButzkueven, H
dc.contributor.authorCarroll, WM
dc.contributor.authorChapman, C
dc.contributor.authorKermode, AG
dc.contributor.authorMarriott, M
dc.contributor.authorMason, D
dc.contributor.authorHeard, RN
dc.contributor.authorPender, MP
dc.contributor.authorSlee, M
dc.contributor.authorTubridy, N
dc.contributor.authorWilloughby, E
dc.date.available2016-03-03T01:09:48Z
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.issued2009-07-01
dc.identifierpii: ng.396
dc.identifier.citationBahlo, M., Booth, D. R., Broadley, S. A., Brown, M. A., Foote, S. J., Griffiths, L. R., Kilpatrick, T. J., Lechner-Scott, J., Moscato, P., Perreau, V. M., Rubio, J. P., Scott, R. J., Stankovich, J., Stewart, G. J., Taylor, B. V., Wiley, J., Clarke, G., Cox, M. B., Csurhes, P. A. ,... Willoughby, E. (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. NATURE GENETICS, 41 (7), pp.824-U84. https://doi.org/10.1038/ng.396.
dc.identifier.issn1061-4036
dc.identifier.urihttp://hdl.handle.net/11343/59099
dc.description.abstractTo identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 x 10(-11); rs10876994, P = 2.7 x 10(-10); rs12368653, P = 1.0 x 10(-7)) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 x 10(-7); rs1569723, P = 2.9 x 10(-7)). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleGenome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
dc.typeJournal Article
dc.identifier.doi10.1038/ng.396
melbourne.affiliation.departmentMedicine, Dentistry & Health Sciences
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMelbourne Medical School
melbourne.affiliation.departmentEducation Unit, MDHS
melbourne.affiliation.departmentRadiology
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentSchool of Biomedical Sciences
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentCentre for Neuroscience
melbourne.affiliation.departmentPathology
melbourne.source.titleNATURE GENETICS
melbourne.source.volume41
melbourne.source.issue7
melbourne.source.pages824-U84
melbourne.identifier.arcLP0776744
melbourne.elementsid318411
melbourne.contributor.authorFOOTE, SIMON
melbourne.contributor.authorKilpatrick, Trevor
melbourne.contributor.authorPerreau, Victoria
melbourne.contributor.authorRubio, Justin
melbourne.contributor.authorField, Judith
melbourne.contributor.authorButzkueven, Helmut
melbourne.contributor.authorMARRIOTT, MARK
melbourne.contributor.authorWILKINS, ELLA
melbourne.contributor.authorWiley, James
melbourne.contributor.authorBahlo, Melanie
dc.identifier.eissn1546-1718
melbourne.identifier.fundernameidMULTIPLE SCLEROSIS RESEARCH AUST, LP0776744
pubs.acceptance.date2009-04-29
melbourne.accessrightsThis item is currently not available from this repository


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