Association of breast cancer with quantitative mammographic density measures for women receiving contrast-enhanced mammography
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Date
2024
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JNCI Cancer Spectrum
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Oxford University Press
Melbourne Authors
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Melbourne School of Population and Global Health
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Journal Article
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Watt, G. P., Keshavamurthy, K. N., Nguyen, T. L., Lobbes, M. B., Jochelson, M. S., Sung, J. S., Moskowitz, C. S., Patel, P., Liang, X., Woods, M., Hopper, J. L., Pike, M. C. & Bernstein, J. L. (2024). Association of breast cancer with quantitative mammographic density measures for women receiving contrast-enhanced mammography. JNCI Cancer Spectrum, 8 (3), https://doi.org/10.1093/jncics/pkae026.
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Abstract
Women with high mammographic density have an increased risk of breast cancer. They may be offered contrast-enhanced mammography to improve breast cancer screening performance. Using a cohort of women receiving contrast-enhanced mammography, we evaluated whether conventional and modified mammographic density measures were associated with breast cancer. Sixty-six patients with newly diagnosed unilateral breast cancer were frequency matched on the basis of age to 133 cancer-free control individuals. On low-energy craniocaudal contrast-enhanced mammograms (equivalent to standard mammograms), we measured quantitative mammographic density using CUMULUS software at the conventional intensity threshold (“Cumulus”) and higher-than-conventional thresholds (“Altocumulus,” “Cirrocumulus”). The measures were standardized to enable estimation of odds ratio per adjusted standard deviation (OPERA). In multivariable logistic regression of case-control status, only the highest-intensity measure (Cirrocumulus) was statistically significantly associated with breast cancer (OPERA = 1.40, 95% confidence interval = 1.04 to 1.89). Conventional Cumulus did not contribute to model fit. For women receiving contrast-enhanced mammography, Cirrocumulus mammographic density may better predict breast cancer than conventional quantitative mammographic density.