Highly impulsive rats: Modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction
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Date
2013-03-01
Source Title
Disease Models & Mechanisms
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COMPANY BIOLOGISTS LTD
Melbourne Authors
Affiliation
Florey Department of Neuroscience and Mental Health
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Journal Article
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Jupp, B., Caprioli, D. & Dalley, J. W. (2013). Highly impulsive rats: Modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction. Dmm Disease Models and Mechanisms, 6 (2), pp.302-311. https://doi.org/10.1242/dmm.010934.
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Abstract
Impulsivity describes the tendency of an individual to act prematurely without foresight and is associated with a number of neuropsychiatric co-morbidities, including drug addiction. As such, there is increasing interest in the neurobiological mechanisms of impulsivity, as well as the genetic and environmental influences that govern the expression of this behaviour. Tests used on rodent models of impulsivity share strong parallels with tasks used to assess this trait in humans, and studies in both suggest a crucial role of monoaminergic corticostriatal systems in the expression of this behavioural trait. Furthermore, rodent models have enabled investigation of the causal relationship between drug abuse and impulsivity. Here, we review the use of rodent models of impulsivity for investigating the mechanisms involved in this trait, and how these mechanisms could contribute to the pathogenesis of addiction.
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REACTION-TIME-TASK, NUCLEUS-ACCUMBENS CORE, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, SPONTANEOUSLY HYPERTENSIVE-RAT, DELAY-DISCOUNTING TASK, DEFICIT HYPERACTIVITY DISORDER, INHIBITORY RESPONSE CONTROL, DOPAMINE D2 RECEPTORS, SPRAGUE-DAWLEY RATS, STOP-SIG, REACTION-TIME-TASK, NUCLEUS-ACCUMBENS CORE, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, SPONTANEOUSLY HYPERTENSIVE-RAT, DELAY-DISCOUNTING TASK, DEFICIT HYPERACTIVITY DISORDER, INHIBITORY RESPONSE CONTROL, DOPAMINE D2 RECEPTORS, SPRAGUE-DAWLEY RATS, STOP-SIG