C-reactive protein and glucose regulation in familial longevity
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2011-12-01
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Age
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SPRINGER
Melbourne Authors
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Medicine (RMH)
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Journal Article
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Rozing, M. P., Mooijaart, S. P., Beekman, M., Wijsman, C. A., Maier, A. B., Bartke, A., Westendorp, R. G. J., Slagboom, E. P. & Van Heemst, D. (2011). C-reactive protein and glucose regulation in familial longevity. Age, 33 (4), pp.623-630. https://doi.org/10.1007/s11357-011-9206-8.
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Abstract
Earlier, we showed that the offspring from exceptionally long-lived families have a more favorable glucose metabolism when compared with controls. As chronic low-grade inflammation has been regarded as a strong risk factor for insulin resistance, we evaluated if and to what extent the favorable glucose metabolism in offspring from long-lived families could be explained by differences in subclinical inflammation, as estimated from circulating levels of C-reactive protein. We found no difference between the two groups in C-reactive protein levels or in the distribution of C-reactive protein haplotypes. However, among controls higher levels of C-reactive protein were related to higher glucose levels, whereas among offspring levels of C-reactive protein were unrelated to glucose levels. It is a limitation of the current study that its cross-sectional nature does not allow for assessment of cause-effect relationships. One possible interpretation of these data is that the offspring from long-lived families might be able to regulate glucose levels more tightly under conditions of low-grade inflammation. To test this hypothesis, our future research will be focused on assessing the robustness of insulin sensitivity in response to various challenges in offspring from long-lived families and controls.