Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
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Date
2012
Source Title
Pathobiology of Aging & Age-related Diseases
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TAYLOR & FRANCIS LTD
Melbourne Authors
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Clinical Pathology
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Journal Article
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Rafehi, H., Ververis, K., Balcerczyk, A., Ziemann, M., Ooi, J., Hu, S., Kwa, F. A. A., Loveridge, S. J., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C. (2012). Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis. PATHOBIOLOGY OF AGING AND AGE-RELATED DISEASES, 2 (1), https://doi.org/10.3402/pba.v2i0.11905.
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Abstract
The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.