Salmonella-specific CD4+ T cells in the murine model of Salmonellosis
No Preview Available
Citations
Altmetric:
Altmetric::
Download
Associated Records
Authors
File Licence
Editors
Date
2024-03
Source Title
Journal Title
Journal ISSN
Volume Title
Publisher
Melbourne Authors
Affiliation
Microbiology & Immunology
Document Type
PhD thesis
Subject Code
Citation
Access Status
This item is embargoed and will be available on 2027-03-04.
DOI
Access URL
Open Access URL
Open Access at PMC
Linked Resource URL
NHMRC Grant Code
ARC Grant Code
Description
© 2025 Adrian David Semeniuk
Abstract
Salmonella infection is a major cause of morbidity and mortality worldwide, and the development of effective vaccines requires a better understanding of the protective immune mechanisms. The importance of CD4+ T cells during Salmonellosis is well established, but antigenic targets, in vivo dynamics and the phenotype of Salmonella-specific CD4+ T cells are less than fully resolved. In this project, four antigenic targets were selected from a novel Salmonella-derived MHC class II immunopeptidome and respective MHC class II tetramers generated, which enabled the direct identification, enumeration and characterization of so far unreported Salmonella-specific CD4+ T cells during murine Salmonellosis. Our results demonstrate the feasibility and utility of using immunopeptidomics and tetramer technology to study Salmonella-specific CD4+ T cell immunity in a murine model of Salmonellosis. Furthermore, the novel antigens and tetramers provide valuable tools for next-generation vaccine development against Salmonella.
Notes
Terms of Use
Keywords
Salmonella, CD4+ T cells, MHC class II tetramer