Safety of inhaled (Tobi®) and intravenous tobramycin in young children with cystic fibrosis
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2014-01-01
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Journal of Cystic Fibrosis
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ELSEVIER SCIENCE BV
Melbourne Authors
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Paediatrics (RCH)
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Journal Article
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Hennig, S., McKay, K., Vidmar, S., O'Brien, K., Stacey, S., Cheney, J. & Wainwright, C. E. (2014). Safety of inhaled (Tobi®) and intravenous tobramycin in young children with cystic fibrosis. Journal of Cystic Fibrosis, 13 (4), pp.428-434. https://doi.org/10.1016/j.jcf.2014.01.014.
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Abstract
BACKGROUND: Use of inhaled tobramycin therapy for treatment of Pseudomonas aeruginosa infections in young children with cystic fibrosis (CF) is increasing. Safety data for pre-school children are sparse. METHODS: The aim of this study was to assess the safety of tobramycin solution for inhalation (TOBI®-TSI) administered twice daily for 2 months/course concurrently to intravenous (IV) tobramycin during P. aeruginosa eradication therapy in children (0-5 years). Audiological assessment and estimation of glomerular filtration rate (GFR) was measured prior to any exposure and end of the study. RESULTS: Data were available from 142 patients who were either never exposed to aminoglycosides (n=39), exposed to IV aminoglycosides only (n=36) or exposed to IV+TSI (n=67). Median exposure to TSI was 113 days [59, 119]. Comparison of effects on audiometry results and GFR, showed no detectable difference between the groups. CONCLUSIONS: Use of TSI and IV tobramycin in pre-school children with CF was not associated with detectable renal toxicity or ototoxicity.