ACE1 polymorphism and progression of SARS
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2004-10-22
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Biochemical and Biophysical Research Communications
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Elsevier BV
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Asia Institute
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Journal Article
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Itoyama, S., Keicho, N., Quy, T., Phi, N. C., Long, H. T., Ha, L. D., Ban, V. V., Ohashi, J., Hijikata, M., Matsushita, I., Kawana, A., Yanai, H., Kirikae, T., Kuratsuji, T. & Sasazuki, T. (2004). ACE1 polymorphism and progression of SARS. Biochemical and Biophysical Research Communications, 323 (3), pp.1124-1129. https://doi.org/10.1016/j.bbrc.2004.08.208.
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Abstract
We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p=0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.