Polymer Capsules for Plaque-Targeted In Vivo Delivery
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Date
2016-09-01
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Advanced Materials
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WILEY-V C H VERLAG GMBH
Melbourne Authors
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Chemical and Biomolecular Engineering
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Journal Article
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Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., Cui, J., Law, L. S., Hagemeyer, C. E. & Caruso, F. (2016). Polymer Capsules for Plaque-Targeted In Vivo Delivery. Advanced Materials, 28 (35), pp.7703-7707. https://doi.org/10.1002/adma.201601754.
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Abstract
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques.