Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes
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2020-12-01
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Trends in Endocrinology and Metabolism
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Elsevier BV
Melbourne Authors
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Medicine (Austin & Northern Health)
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Journal Article
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Gurzov, E. N., Ke, P. C., Ahlgren, U., Garcia Ribeiro, R. S. & Gotthardt, M. (2020). Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes. Trends in Endocrinology and Metabolism, 31 (12), pp.905-917. https://doi.org/10.1016/j.tem.2020.10.002.
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Abstract
A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 diabetes is currently hampered by a lack of reliable techniques to restore β cell survival, to improve insulin secretion, and to quantify β cell mass in patients. Current new approaches may allow us to precisely and specifically visualize β cells in vivo and provide viable therapeutic strategies to preserve, recover, and regenerate β cells. In this review, we discuss recent protective approaches for β cells and the advantages and limitations of current imaging probes in the field.