Visual spatial learning outcomes for clinical trials in neurofibromatosis type 1
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Date
2020-02-01
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Annals of Clinical and Translational Neurology
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WILEY
Melbourne Authors
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Paediatrics (RCH)
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Journal Article
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Ullrich, N. J., Payne, J. M., Walsh, K. S., Cutter, G., Packer, R., North, K. & Rey-Casserly, C. (2020). Visual spatial learning outcomes for clinical trials in neurofibromatosis type 1. Annals of Clinical and Translational Neurology, 7 (2), pp.245-249. https://doi.org/10.1002/acn3.50976.
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Abstract
Cognitive problems are common in children with neurofibromatosis type 1, representing a significant source of lifelong morbidity. Assessment of cognitive function has been challenging in the setting of clinical trials. Spatial learning deficits may be an important target for cognitive interventions. We leveraged a large, international cognitive study in affected children with NF1 treated with lovastatin to assess spatial learning using the "Arena Maze", a portable, computerized task that allows for retesting in the same environment. As with the parent study, spatial learning assessed with this task did not improve with lovastatin treatment.