An intoxication involving 2-methyl AP-237 and AP-238 from Victoria, Australia: Case report
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2024-01
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Drug Testing and Analysis
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Wiley
Melbourne Authors
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Critical Care
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Journal Article
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Maplesden, J., Greene, S., Syrjanen, R., Di Rago, M. & Schumann, J. (2024). An intoxication involving 2-methyl AP-237 and AP-238 from Victoria, Australia: Case report. Drug Testing and Analysis, 16 (1), pp.93-98. https://doi.org/10.1002/dta.3524.
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Indeed, NSO reported to the United Nations Office on Drugs and Crime between 2015 and 2019 grew from 2 to 8% of all reported novel psychoactive substances. To date, little has been published on non-fentanyl synthetic opioid use in Australia. AP-238 and 2-Methyl AP-237 are non-fentanyl synthetic opioids, which exhibit µ-opioid receptor agonism with substantially lower potency than fentanyl. 2-Methyl AP-237 was first identified in 2019 in drug seizures as an encapsulated white powder and in forensic toxicological analysis in Europe and the United States (US). AP-238 was first identified within the illicit drug market in the US and Slovenia in 2020. We report a case of analytically confirmed 2-methyl AP-237 and AP-238 use in a patient presenting to an emergency department, as part of the Emerging Drugs Network of Australia - Victoria project.