A method using goldmann stimulus sizes I to V-measured sensitivities to predict lead time gained to visual field defect detection in early glaucoma
Loading...
Download
Associated Records
Authors
File Licence
Editors
Date
2018-05-01
Source Title
Translational Vision Science & Technology
Journal Title
Journal ISSN
Volume Title
Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Melbourne Authors
Affiliation
Anatomy and Neuroscience
Optometry and Vision Sciences
Optometry and Vision Sciences
Document Type
Journal Article
Subject Code
Citation
Phu, J., Khuu, S. K., Bui, B. V. & Kalloniatis, M. (2018). A method using goldmann stimulus sizes I to V-measured sensitivities to predict lead time gained to visual field defect detection in early glaucoma. Translational Vision Science and Technology, 7 (3), https://doi.org/10.1167/tvst.7.3.17.
Access Status
Open Access
Access URL
Open Access URL
Open Access at PMC
Linked Resource URL
NHMRC Grant Code
ARC Grant Code
Description
Abstract
PURPOSE: To predict the lead time (difference in time taken for a visual field [VF] defect to be detected) obtained when using stimulus sizes within or near the size of the critical area of spatial summation (Ac), and to test these predictions using sensitivity measurements from a cohort of glaucoma patients. METHODS: Thirty-seven patients with early open-angle glaucoma and 60 healthy observers underwent VF testing on the Humphrey Field Analyzer in full threshold mode using Goldmann stimulus sizes I to V (GI-V) across the 30-2 test grid. We used the sensitivities measured using GI to V in healthy patients to predict the lead time gained by using stimulus sizes within the size of Ac at all locations within the 30-2 grid. Then, we used sensitivities measured in the glaucoma patients to test this predictive model. RESULTS: Median lead time to VF defect detection when using stimulus sizes within Ac compared with stimulus sizes larger than Ac was 4.1 years across the 30-2 test grid (interquartile range, 3.1 and 5.1 years). Sensitivities of the glaucoma patients showed good agreement with the predictive model of lead time gained (77.5%-84.3% were within ±3 dB). CONCLUSIONS: Our model predicted substantial lead time differences when using stimulus sizes within or near Ac. Such stimulus sizes could potentially detect VF defects, on average, 4 years earlier than current paradigms. TRANSLATIONAL RELEVANCE: Stimulus sizes within or near Ac may be more suitable for early detection of glaucomatous VF defects. Larger stimulus sizes may be more suitable for later monitoring of established disease.