Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
Loading...
Citations
Web of Science:
Altmetric:
Altmetric::
Download
Associated Records
Authors
File Licence
Editors
Date
2018-10-12
Source Title
Frontiers in Synaptic Neuroscience
Journal Title
Journal ISSN
Volume Title
Publisher
FRONTIERS RESEARCH FOUNDATION
Melbourne Authors
Affiliation
Florey Department of Neuroscience and Mental Health
Document Type
Journal Article
Subject Code
Citation
Lalanne, T., Oyrer, J., Farrant, M. & Sjostrom, P. J. (2018). Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors. FRONTIERS IN SYNAPTIC NEUROSCIENCE, 10, https://doi.org/10.3389/fnsyn.2018.00034.
Access Status
Open Access
Access URL
Open Access URL
Open Access at PMC
Linked Resource URL
NHMRC Grant Code
ARC Grant Code
Description
Abstract
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.