T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time
Loading...
Citations
Scopus:
Altmetric:
Altmetric::
Download
Associated Records
Authors
File Licence
Editors
Date
2019-05-01
Source Title
Immunological Reviews
Journal Title
Journal ISSN
Volume Title
Publisher
WILEY
Melbourne Authors
Affiliation
Microbiology and Immunology
Document Type
Journal Article
Subject Code
Citation
Ugur, M. & Mueller, S. N. (2019). T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time. Immunological Reviews, 289 (1), pp.115-128. https://doi.org/10.1111/imr.12753.
Access Status
Open Access
Access URL
Open Access URL
Open Access at PMC
Linked Resource URL
NHMRC Grant Code
ARC Grant Code
Description
Abstract
The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular interactions required for optimal priming of effector and memory T cell responses are beginning to be unraveled. Here we review advances in our understanding of how T cell priming is choreographed during infections, highlight the importance of cell positioning in this process and discuss how a spectrum of cellular interactions shapes T cell activation and differentiation.