Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

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Authors
Hadoux, X; Hui, F; Lim, JKH; Masters, CL; Pébay, A; Chevalier, S; Ha, J; Loi, S; Fowler, CJ; Rowe, C...
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Date
2019-12-01
Source Title
Nature Communications
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Publisher
NATURE PUBLISHING GROUP
Melbourne Authors
Loi, Samantha ORCID
 Nguyen, Christine ORCID
 Pebay, Alice ORCID
 Lim, Jeremiah ORCID
 Hadoux, Xavier
Van Wijngaarden, Peter ORCID
 Masters, Colin ORCID
 Bui, Bang ORCID
 Dirani, Mohamed
Williamson, Robert
Rowe, Christopher ORCID
 Villemagne, Victor ORCID
 Fowler, Christopher ORCID
 Crowston, Jonathan
Hui, Flora ORCID
Affiliation
Florey Department of Neuroscience and Mental Health
Centre for Eye Research Australia (CERA)
Paediatrics (RCH)
Optometry and Vision Sciences
Medicine (Austin & Northern Health)
Surgery (RMH)
Psychiatry
Ophthalmology (Eye & Ear Hospital)
Document Type
Journal Article
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Citation
Hadoux, X., Hui, F., Lim, J. K. H., Masters, C. L., Pébay, A., Chevalier, S., Ha, J., Loi, S., Fowler, C. J., Rowe, C., Villemagne, V. L., Taylor, E. N., Fluke, C., Soucy, J. P., Lesage, F., Sylvestre, J. P., Rosa-Neto, P., Mathotaarachchi, S., Gauthier, S. ,... van Wijngaarden, P. (2019). Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease. Nature Communications, 10 (1), https://doi.org/10.1038/s41467-019-12242-1.
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Open Access
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https://hdl.handle.net/11343/233839
DOI
10.1038/s41467-019-12242-1
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Open Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748929
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ARC Grant Code
ARC/LP160100126
Description
Abstract
Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aβ in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aβ load.
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CC BY
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https://doi.org/10.1038/s41467-019-12242-1
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Florey Department of Neuroscience and Mental Health - Research Publications
Centre for Eye Research Australia (CERA) - Research Publications
Medicine (Austin & Northern Health) - Research Publications
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Ophthalmology (Eye & Ear Hospital) - Research Publications
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