TY  - JOUR
AU  - Siebel, AL
AU  - Gehring, HM
AU  - Vodstrcil, L
AU  - Parry, LJ
Y2  - 2017/10/04
Y1  - 2005/01/01
SN  - 0077-8923
UR  - http://hdl.handle.net/11343/192568
AB  - Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice. An increase in ERalpha in Rlx+/+ mice at term was correlated with a decrease in ERbeta, which was not observed in Rlx-/- mice. Treatment of Rlx-/- mice with relaxin had no effect on OTR, LGR7, or ERalpha expression, but it caused a significant decrease in ERbetas.
LA  - English
PB  - NEW YORK ACAD SCIENCES
T1  - Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx(-/-)) mice
DO  - 10.1196/annals.1282.014
IS  - Annals of the New York Academy of Sciences
VL  - 1041
IS  - 1
SP  - 104-109
ER  -