TY - JOUR AU - Siebel, AL AU - Gehring, HM AU - Vodstrcil, L AU - Parry, LJ Y2 - 2017/10/04 Y1 - 2005/01/01 SN - 0077-8923 UR - http://hdl.handle.net/11343/192568 AB - Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice. An increase in ERalpha in Rlx+/+ mice at term was correlated with a decrease in ERbeta, which was not observed in Rlx-/- mice. Treatment of Rlx-/- mice with relaxin had no effect on OTR, LGR7, or ERalpha expression, but it caused a significant decrease in ERbetas. LA - English PB - NEW YORK ACAD SCIENCES T1 - Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx(-/-)) mice DO - 10.1196/annals.1282.014 IS - RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE VL - 1041 IS - 1 SP - 104-109 ER -