TY  - JOUR
AU  - Beyer, L
AU  - Nitschmann, A
AU  - Barthel, H
AU  - van Eimeren, T
AU  - Unterrainer, M
AU  - Sauerbeck, J
AU  - Marek, K
AU  - Song, M
AU  - Palleis, C
AU  - Respondek, G
AU  - Hammes, J
AU  - Barbe, MT
AU  - Onur, O
AU  - Jessen, F
AU  - Saur, D
AU  - Schroeter, ML
AU  - Rumpf, J-J
AU  - Rullmann, M
AU  - Schildan, A
AU  - Patt, M
AU  - Neumaier, B
AU  - Barret, O
AU  - Madonia, J
AU  - Russell, DS
AU  - Stephens, AW
AU  - Roeber, S
AU  - Herms, J
AU  - Boetzel, K
AU  - Levin, J
AU  - Classen, J
AU  - Hoeglinger, GU
AU  - Bartenstein, P
AU  - Villemagne, V
AU  - Drzezga, A
AU  - Seibyl, J
AU  - Sabri, O
AU  - Brendel, M
Y2  - 2020/11/17
Y1  - 2020/04/21
SN  - 1619-7070
UR  - http://hdl.handle.net/11343/251469
AB  - PURPOSE: Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). METHODS: Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0-60 min p.i.) and static [18F]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. RESULTS: Highest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers. CONCLUSION: Early-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.
LA  - English
PB  - SPRINGER
T1  - Early-phase [F-18]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
DO  - 10.1007/s00259-020-04788-w
IS  - European Journal of Nuclear Medicine and Molecular Imaging
VL  - 47
IS  - 12
SP  - 2911-2922
L1  - /bitstream/handle/11343/251469/PMC7567714.pdf?sequence=1&isAllowed=y
ER  -