TY  - JOUR
AU  - Catalan, A
AU  - Tognin, S
AU  - Kempton, MJ
AU  - Stahl, D
AU  - Salazar de Pablo, G
AU  - Nelson, B
AU  - Pantelis, C
AU  - Riecher-Rössler, A
AU  - Bressan, R
AU  - Barrantes-Vidal, N
AU  - Krebs, M-O
AU  - Nordentoft, M
AU  - Ruhrmann, S
AU  - Sachs, G
AU  - Rutten, BPF
AU  - van Os, J
AU  - de Haan, L
AU  - van der Gaag, M
AU  - EU-GEI High Risk Study
AU  - Valmaggia, LR
AU  - McGuire, P
Y2  - 2020/11/26
Y1  - 2020/10/06
SN  - 0033-2917
UR  - http://hdl.handle.net/11343/252205
AB  - BACKGROUND: Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. METHODS: In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. RESULTS: There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ. CONCLUSIONS: In CHR participants, JTC at baseline was associated with adverse functioning at the follow-up. Interventions designed to improve JTC could be beneficial in the CHR population.
LA  - eng
PB  - Cambridge University Press (CUP)
T1  - Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis.
DO  - 10.1017/S0033291720003396
IS  - Psychological Medicine
SP  - 1-9
L1  - /bitstream/handle/11343/252205/div-class-title-relationship-between-jumping-to-conclusions-and-clinical-outcomes-in-people-at-clinical-high-risk-for-psychosis-div.pdf?sequence=1&isAllowed=y
ER  -