TY  - JOUR
AU  - Yi, X
AU  - Xue, L
AU  - Thomas, T
AU  - Baell, JB
Y2  - 2020/11/27
Y1  - 2020/03/01
SN  - 1756-8919
UR  - http://hdl.handle.net/11343/252365
AB  - Here, we describe our action plan for hit identification (APHID) that guides the process of hit triage, with elimination of less tractable hits and retention of more tractable hits. We exemplify the process with reference to our high-throughput screening (HTS) campaign against the enzyme, KAT6A, that resulted in successful identification of a tractable hit. We hope that APHID could serve as a useful, concise and digestible guide for those involved in HTS and hit triage, especially those that are relatively new to this exciting and continually evolving technology.
LA  - English
PB  - FUTURE SCI LTD
T1  - Action plan for hit identification (APHID): KAT6A as a case study
DO  - 10.4155/fmc-2019-0212
IS  - Future Medicinal Chemistry
VL  - 12
IS  - 5
SP  - 423-438
L1  - /bitstream/handle/11343/252365/fmc-2019-0212.pdf?sequence=1&isAllowed=y
ER  -