TY  - JOUR
AU  - Chatzi, G
AU  - Mason, T
AU  - Chandola, T
AU  - Whittaker, W
AU  - Howarth, E
AU  - Cotterill, S
AU  - Ravindrarajah, R
AU  - McManus, E
AU  - Sutton, M
AU  - Bower, P
Y2  - 2020/11/27
Y1  - 2020/09/01
SN  - 0742-3071
UR  - http://hdl.handle.net/11343/252442
AB  - Aim
To explore whether there are social inequalities in non‐diabetic hyperglycaemia (NDH) and in transitions to type 2 diabetes mellitus and NDH low‐risk status in England.

Methods
Some 9143 men and women aged over 50 years were analysed from waves 2, 4, 6 and 8 (2004–2016) of the English Longitudinal Study of Ageing (ELSA). Participants were categorized as: NDH ‘low‐risk’ [HbA1c < 42 mmol/mol (< 6.0%)], NDH [HbA1c 42–47 mmol/mol (6.0–6.4%)] and type 2 diabetes [HbA1c > 47 mmol/mol (> 6.4%)]. Logistic regression models estimated the association between sociodemographic characteristics and NDH, and the transitions from NDH to diagnosed or undiagnosed type 2 diabetes and low‐risk status in future waves.

Results
NDH was more prevalent in older participants, those reporting a disability, those living in deprived areas and in more disadvantaged social classes. Older participants with NDH were less likely to progress to undiagnosed type 2 diabetes [odds ratio (OR) 0.27, 95% confidence interval (CI) 0.08, 0.96]. NDH individuals with limiting long‐standing illness (OR 1.72, 95% CI 1.16, 2.53), who were economically inactive (OR 1.60, 95% CI 1.02, 2.51) or from disadvantaged social classes (OR 1.63, 95% CI 1.02, 2.61) were more likely to progress to type 2 diabetes. Socially disadvantaged individuals were less likely (OR 0.64, 95% CI 0.41, 0.98) to progress to NDH low‐risk status.

Conclusions
There were socio‐economic differences in NDH prevalence, transition to type 2 diabetes and transition to NDH low‐risk status. Disparities in transitions included the greater likelihood of disadvantaged social groups with NDH developing type 2 diabetes and greater likelihood of advantaged social groups with NDH becoming low‐risk. These socio‐economic differences should be taken into account when targeting prevention initiatives.
LA  - English
PB  - Wiley
T1  - Sociodemographic disparities in non-diabetic hyperglycaemia and the transition to type 2 diabetes: evidence from the English Longitudinal Study of Ageing
DO  - 10.1111/dme.14343
IS  - Diabetic Medicine
VL  - 37
IS  - 9
SP  - 1536-1544
L1  - /bitstream/handle/11343/252442/dme.14343.pdf?sequence=1&isAllowed=y
ER  -